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Director, Cancer Systems Therapeutics


San Diego, CA
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Job Details

Job Title Director, Cancer Systems Therapeutics

JobID 1046741-1852

Location: San Diego, CA

Description *About Pfizer*

A career at Pfizer offers opportunity, ownership and impact.All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

*Role Description*

Reduce to practice the strategic vision of bringing first in class oncology therapies to the clinic and of significantly improving probability of success across the portfolio. Design and implement a strategy to direct cancer systems biology efforts for drug discovery programs.Reports to CSO for Tumor Cell Biology (TCB). Interacts with Medicinal Chemistry, Oncology Business Unit (OBU) and scientists across Oncology Research Unit (ORU) and Worldwide R&D organization.


*Build and lead a team of scientists dedicated to Cancer Systems Biology, Target Validation and Drug Discovery in collaboration with partner lines*Dovetail chemical biology, genetics, molecular profiling and computational biology discovery strategies for parallel development of targets together with their biological and pathophysiological context to advance small molecule portfolio *Identify, develop, and manage external collaborations with world class experts to advance our competitive advantage in improved target validation and drug discovery*Participate in nomination of productive targetable biology downstream of chemical biology and systems biology discovery strategies*Partner with expertise across WRD to productively integrate data/information that enhances understanding of target biology*Ensure scientific rigor across team and focus resources towards TCB and company goals*Contribute to building a culture that embraces continuous learning and improvement, increasing technical skill base and disease biology expertise; take a proactive role in personal growth and scientific developmentSupervision:*Direct supervision of lab leaders and scientists in the Cancer Systems Therapeutics group*Management of external collaborations


*PhD or MD/PhD plus post-doctoral training in Cell Biology, Molecular Biology, Biochemistry, Systems Biology, Genetics, (or a comparable biological science) with a cancer-related focus*Deep and broad knowledge of targets and pathways of importance to cancer biology*Established expert in signal transduction; with deep understanding of challenges and opportunities associated with the current discovery landscape*Knowledgeable in mechanism of drug resistance; highly familiarized with design of drug combination studies; tumor heterogeneity, tumor/host interactions*Expertise in advanced in vitro and in vivo models; good understanding of relevant methodologies*Effective manager of scientific teamsPrior Experience Preferred:*At least 12 years' experience working primarily on cancer biology*At least 8-10 years' experience in industry or academic lab focused on target validation, drug discovery and development*Demonstrated ability to identify, develop, and manage successful external collaborations*Excels in a transdisciplinary team environment; excellent communication skills*Demonstrated success in designing and implementing competitive strategy*Track record of innovation - designing and delivering novel solutions to challenging problems*Track record of productive mentorship

*EEO & Employment Eligibility*

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

*Director, Cancer Systems Therapeutics*
*San Diego,California*

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