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Director, Global Investigative Toxicology

Pfizer


Location:
San Diego, CA
Date:
02/02/2018
2018-02-022018-03-05
Pfizer
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Job Details

This is a scientific and business leadership position in the Global Investigative Toxicology line (~30 colleagues) in Global Drug Safety Research and Development (DSRD; ~450 colleagues). The intent of this role is to: 1) explore, implement and apply new in vitro target organ safety assays; 2) contribute to de-risking toxicology issues in portfolio programs across WRD's Therapeutic Areas and all drug development stages (idea-registration); 3) champion and expand the scientific breadth and depth of the Investigative Toxicology discipline at Pfizer; and 4) develop the next generation of Investigative Toxicology scientists and leaders. As a member of the Global Investigative Leadership team, this role is responsible for: 1) critical scientific and business evaluation of new technologies, assays and scientific/regulatory advancements, including their successful implementation across DSRD; 2) appropriate training, compliance, performance management and other business-related activities of direct reports; and 3) oversight of laboratory expenditures and operations, including laboratory safety and equipment calibration, data capture, QC reporting and archiving. This role will also identify and cultivate effective partnerships with other global disciplines within DSRD (such as Biomarkers and Pathology), as well as nonclinical and clinical disciplines outside of DSRD, facilitating the nonclinical to clinical translation of investigative toxicology endpoints or mechanistic hypotheses.







The incumbent will lead a group of 5-8 investigative scientists utilizing a variety of implemented and new target organ safety assays (e.g., bone marrow, GI, kidney, lung, ocular, skin, CV, pancreas) to provide mechanistic understanding of toxicity signals and/or differentiate compounds across WRD's Therapeutic Areas. The incumbent will effectively communicate and collaborate with other Investigative Toxicology leads to manage the overall portfolio and SnT workload (flexing resources as needed) and to further develop the skill sets of Investigative Toxicology colleagues in both LJ and Groton. Prior scientific experience in developing and applying organ-specific in vitro models for compound screening or differentiation, mechanistic de-risking of unexpected in vitro or in vivo toxicology findings, assessing nonclinical to clinical translation, the development of new in vitro safety screens and/or communicating safety finding to regulatory colleagues are highly desirable.







**ROLE RESPONSIBILITIES**







+ Reports to the Executive Director, Global Investigative Toxicology.



+ A member of the Global Investigative Leadership Team (LT).



+ Effectively collaborates and communicates with other LT members to deliver the portfolio, balance workload across sites and develop colleagues.



+ Supports portfolio programs from a variety of sites and therapeutic areas.



+ Draws from Global Investigative Toxicology staff (considering skill set and workload) to deliver investigative toxicology data with speed and quality to efficiently support portfolio progression/mechanistic understanding.



+ Recruits, trains, develops, motivates highly skilled colleagues across Global Investigative Toxicology groups and sites.



+ Positions DSRD to rapidly and effectively evaluate nonclinical assays or study endpoints, identifies key data gaps and prioritizes them to improve the overall quality and mechanistic understanding of investigative toxicology assays and data interpretation.



+ Engages in critical scientific and business evaluation of new technologies, in vitro assays, and scientific or regulatory advancements in the development of small and large molecule therapeutics.



+ Responsible for appropriate training, performance management and other business-related activities of their direct reports. Performs all regulatory responsibilities in compliance with applicable standards.



+ Provides oversight of laboratory expenditures and operations, including laboratory safety and equipment calibration, data capture, QC reporting and archiving.



+ Represents DSRD on relevant teams, providing scientific guidance of projects or strategic leadership.



+ Models DSRD leadership behaviors and values and fosters a rewarding scientific climate.







**QUALIFICATIONS**







+ PhD or equivalent in toxicology, pharmacology, biology or a related field.



+ Appropriate board certification preferred.



+ Experience leading or managing a multi-functional team in a relevant lab- or portfolio-based environment.



+ Excellent verbal and written communication skills.







**EEO & Employment Eligibility**



Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.







**Sunshine Act**



Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.







Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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