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Director, Immuno


San Francisco, CA
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Job Details

Rinat is a South San Francisco biotechnology unit within the Oncology division of Pfizer Worldwide Research & Development, dedicated to doing its part to fulfill Pfizer's mission of working together for a healthier world. Rinat is dedicated to developing new protein and cell-based therapeutics to improve human life by redirecting the immune system against cancer. Rinat researchers use the latest scientific knowledge and apply novel approaches to discover truly innovative Immuno-Oncology therapeutics. Cooperation and support for a high level of scientific freedom is encouraged in this small biotech-like environment to find the best answers to biological questions, with the benefit of large pharma resources.

**Role Description**

We are seeking to hire the head of our tumor microenvironment research. The candidate should be a highly motivated and accomplished scientist with demonstrated expertise in understanding and modulating the suppressive tumor microenvironment. This position is responsible for defining the strategy for Pfizer's large molecule IO intervention targeting the immunosuppressive tumor microenvironment, which includes establishing and implementing new programs to target inhibitory cell types such as tumor infiltrating myeloid cells and suppressive stromal cells. The successful development of new innovative therapeutics will require close collaboration with a variety of inter-disciplinary colleagues including clinicians, protein engineers, and target identification and biomarker researchers.


Primary Duties:

+ Contribute to overall strategy for cancer immunology at Rinat and defining a strategy for large molecule IO intervention targeted to the immunosuppressive tumor microenvironment

+ Supervise and mentor several teams committed to delivering IND-enabling packages over the next 2-4 years

+ Collaborate with immuno-oncology, protein engineering, computational biology, T cell redirecting therapy group and clinical development group to pursue the most promising drug candidates through clinical trials.

+ Supervise a group conducting target validation for new targets

+ Participate in collaboration on novel IO targets with internal and external collaborators.

+ Lead the latest scientific advancements in the field as a thought leader and spokesperson for Pfizer IO research, especially in the field of the tumor microenvironment

+ Contribute to a culture that embraces continuous learning, development, and collaboration Qualifications

+ PhD with 10-15 years post-doctoral training preferred with significant relevant experience in cancer immunotherapy including myeloid biology and/or tumor stroma biology

+ Industry experience, including regulatory agency interaction is highly desired, including experience of target validation and candidate selection

+ Experience managing a large team is essential

+ Knowledge of cellular and molecular immunology

+ Ability to design and supervise all aspects of in vitro and in vivo cancer immunotherapy models

+ Track record of publications and innovation

+ Ability to design and deliver novel solutions to challenging problems

+ Pro-active attitude and strong desire to discover novel biology and potential new drugs

+ Strong oral presentation and communication skills.


Ability to perform complex data analysis

Ability to analyze and interpret work published in the field and use it to place our work in context.


Role requires travel

A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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