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Head of Internal Medicine Research Unit, Translational Science


Cambridge, MA 02139
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Job Details


A leadership role with a major focus on building translational strategies for LD through POC stage projects. This position will be responsible for bringing together preclinical researchers and clinicians from project teams to identify translatable biomarkers which can be used to demonstrate target engagement and functional consequences of target modulation. Furthermore, this role will identify endpoints by which patient populations can be stratified to optimize chances of detecting signs of activity of candidate molecules in early clinical studies. This position will leverage existing relationships with partner lines within ECD and PDM to measure fluid biomarkers, physiological measures and receptor binding to proteins which are markers of disease states in preclinical species as well as available human tissues (e.g. serum, liver biopsies, CSF or postmortem brain tissue). Candidate will work directly with scientists within the Biology Lines to develop quantitative approaches which can be translated to the clinical setting. A key part of the role is to reach out to experts in the IMRU fields of research to stay abreast of emerging developments in the field of biomarkers and signs of clinical activity. Candidate will be a member of the Early Portfolio Team (EPT) and Portfolio Committee (PC). The candidate will work with teams to develop translational biomarker plans starting at PRISM to ensure that each team has a robust plan in place by the FIH endorsement milestone.


+ Major focus on guiding teams to align preclinical and clinical biomarker strategies

+ Serve as key advisor to above asset biomarker teams (Neuroinflammation, NASH, etc)

+ Act as an expert consultant and collaborator working with researchers within the biology and clinical lines to investigate novel translational endpoints

+ Lead and coordinate collaborative efforts to identify translational biomarkers across a range of modalities (e.g. imaging, fluid biomarkers, EEG)

+ Coordinate new translational approaches to support the late stage IMRU portfolio

+ As a member of the IMRU EPT and PC, ensure that, at LD transition, teams have a draft translational plan which will be developed in parallel with efforts to identify a CAN molecule

+ Ensure teams develop robust and actionable translational plans to support progression of projects from CAN to SOCA

+ Critical interface with Partner lines such as key groups within ECD (specifically imaging, precision medicine, digital medicine) and PDM (e.g. biomarker group) as well as other RUs where appropriate

+ Leverage relationships with preclinical and clinical statistics groups to ensure biomarker studies are adequately powered to detect anticipated effects.

+ Help establish strategic direction, including interdependencies with other Pfizer units and the external environment.

+ Establish a clear strategy for the delivery of portfolio excellence through contributions to project teams across the portfolio to drive consistency and efficiency

+ Facilitate the establishment and maintenance of effective collaborations with academic institutions and patient foundations focused on developing quantitative markers of disease


+ PhD, MD or MD/PhD

+ >10 years experience in translational pharmacology and/or translational medicine with a sound understanding of early clinical development

+ Expertise in one or more of the Internal Medicine disease areas including neurodegeneration (Alzheimer's and Parkinson's Disease), NASH, T2DM and eating disorders

+ Excellent communication skills

+ Proven scientific and people leader with demonstrated l eadership experience of both preclinical and clinical projects

+ Capable of driving strategy and influencing others - demonstrates critical scientific thinking, and success at solving complex problems

+ Ability to effectively facilitate meetings and conduct complex, strategic conversations.

+ Track record of innovation and driving effective change

+ Demonstrated success in negotiating the environment of a highly matrix-based organization

+ Established network of academic and industry collaborators

+ Demonstrated business acumen and understanding of factors contributing to portfolio prioritization

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**Additional Offer Details:**

This job is Pfizer Exempt US Grade: 16

Eligible for Relocation Package

Eligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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