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Head, Transgenic Mouse Models


Andover, MA
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Job Details

Job Title Head, Transgenic Mouse Models

JobID 1611916

Location: Andover, MA

Description Pfizer is increasingly relying on human genetics to inform the discovery and validation of new drug targets and the mechanistic understanding of disease pathology. A necessary component of testing potential targets, whatever the source, is assessment of functional consequences of candidate variants or genes in rodent models, to determine physiological effect and tractability to drug discovery.

The purpose of this unit is to respond to the need for validation of targets arising from mechanistic, genetic, or expression studies by rapidly generating appropriate genetically engineered model systems. The head of the In Vivo Core will be an expert in gene editing and in creation of mouse models and will lead a small, flexible team that collaborates closely with colleagues in disease Research Units, Comparative Medicine, and the Genome Sciences and Technologies departments to create model systems for phenotyping and profiling by research units.

The In Vivo Core will partner with colleagues responsible for in vitro functional genomics to develop overall strategies for testing and prioritizing nominated targets in key disease areas, and will be responsible for testing and applying the latest technical developments in gene editing and transgenic model creation. This is a unique opportunity to play an integral role in executing the strategy of one of the world's leading developers of novel therapeutics. Position could be sited at Andover MA; Pearl River NY; or Groton CT by mutual agreement.

+ Supervise all facets of model generation, including construct preparation, microinjection, and plan animal breeding and back-crossing strategies.

+ Establish a repertoire of functional genomics and molecular biological tools, including gene editing technologies and viral vectors and delivery, and apply to make mouse models of disease for characterization by disease research units. Group is targeted to support the initiation of estimated fifty model lines per year.

+ Establish a working in-house in vivo model generation core in partnership with Comparative Medicine that responds to and proactively partners with Research Units investigating disease, and help establish a seamless gene-to-function pipeline that contributes effectively to decision-making in drug R&D.

+ Maintain and develop the highest standards of compliance with all animal welfare methods and protocols.

+ Develop a strong working relationship with the Human Genetics and Computational groups within Genome Sciences and Technologies, and with the individual Internal Medicine, Inflammation & Immunology, Oncology, and Rare Disease research units, Vaccines and the Centers for Therapeutic Innovation to understand their needs for genetically engineered model systems, explore mutual opportunities, and execute defined projects.

+ Develop productive contractual relationships in partnership with Comparative Medicine with selected external providers, both commercial and academic, to access established technologies and methods in a scalable fashion.

+ Lead internal efforts to test and provide cutting-edge technologies of transgenic model generation, in particular partnership with in vitro functional genomics group.

+ Supervise a small group dedicated to rapid generation of transgenic models and facilitate group scientific and career development.


+ PhD in molecular biology with deep understanding of modern gene editing technologies and creation of genetically engineered animal models, as demonstrated by high-impact scientific publications, with recognition as an expert in the field.

+ PhD plus 4 to 8 years experience, preferably but not necessarily including experience in the pharmaceutical or biotechnology industry.

+ Track record of generation and use of transgenic mice.

+ Experience in a range of functional genomic technologies; solid understanding of bioinformatics tools and computational biology opportunities.

+ Ability to engage closely in multiple projects local and remote and to track record of timely execution.

+ Excellent interpersonal and communication skills. Demonstrated ability to work with teams, establish and cultivate networks, and maintain productive and congenial collaborations.

+ Personnel management experience in coaching and mentoring junior scientists and in generating motivation and passion in a team.

+ Devotion to advancing team goals and enthusiasm for contributing to the mission of drug discovery.

+ physical and mental ability to work with laboratory rodents

+ Ability to travel to Cambridge site to interface with colleagues

+ Adherance to animal facility compliance

+ Interact with RUs and with GST colleagues to determine the best path for target validation. Interact with Comparative Medicine on animal management issues, including with external providers

+ Interact with external scientific experts on gene editing, particularly as applied to efficient creation of genetically modified mouse strains

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**Additional Offer Details:**

+ **Last Date to Apply for Job:** October 1, 2017

+ **This job is (Pfizer) (Exempt) (US/PR) Grade:** 013

+ Additional Location Information: Andover MA; Pearl River NY; or Groton CT

+ Eligible for Relocation Package: yes

+ Eligible for Employee Referral Bonus: yes

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

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