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NGS Technology Center Senior Scientist


Cambridge, MA
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Job Details

We are seeking a motivated and dynamic individual to join the Pfizer NGS Technology Center. This individual would lead the development, validation, implementation, and growth of Next Generation Sequencing (NGS) technologies at Pfizer Kendall Square (KSQ) research campus. This person will provide experimental design support, train scientists across the KSQ research units/partner lines and help execute technical and laboratory aspects of in-house NGS assay development. This individual will also be involved in establishing LIMS processes, defining robust QC criteria and interface with bioinformatics/ computational groups to establish primary NGS data management and analysis pipelines. Meticulous attention to detail, proficient reasoning and problem-solving skills in experimental design required.


+ Drives the implementation and growth of NGS technology application, supports ongoing development, validation and troubleshooting of NGS assays, in particular RNAseq (total or mRNASeq), 3' RNAseq, targeted RNASeq, small RNAseq, and other emerging NGS based applications.

+ Overseas operations of different NGS workflows; from sample preparation, library construction, data generation, and data QC, ensuring high level of quality and reliability of generated results.

+ Effectively optimizing and troubleshooting NGS library preparation using state of the art robotic automation platforms.

+ Maintaining stringent QC processes from sample collection/ isolation all the way to NGS library and sequencing run QC.

+ Interfaces with teams to implement data processing and analysis workflows, bioinformatics pipelines, and data storage procedures

+ Effectively balances resources as needed to achieve timely execution of projects across multiple research units and partner lines.

+ Serves as a subject matter expert for NGS technology, provides guidance on experimental design, method or platform selection, and data management to address a specific need.

+ Educates other scientists and provides hands-on training

+ Stays on top of the scientific and technical innovations in the NGS space in particular, and follows new trends and developments in genomic technologies overall.


**Education And Experience**

+ PhD and previous experience that provides the knowledge, skills, and abilities to perform the job.

+ OR Master's degree and previous experience that provides the knowledge, skills, and abilities to perform the job (comparable 2+ year).

+ OR Bachelor's degree or equivalent and relevant formal academic / vocational qualification

+ Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 4+ years) or equivalent combination of education, training, & experience.

**Knowledge, Skills And Abilities**

+ Must have at least 2 years of documented hands-on (wet lab) experience with NGS assay development, validation, troubleshooting, and reviewing of sequencing run QC data.

+ Must have strong general molecular biology laboratory skills and in depth experience with DNA/RNA extraction, nucleic acid quantitation and quality control analysis.

+ Must have an in-depth knowledge of different NGS applications and technologies.

+ Knowledge of robotic automation of NGS workflows is highly desired.

+ Familiarity with different NGS software platforms, bioinformatics pipelines and NGS data processing and interpretation solutions highly desired.

+ Must have strong organizational and interpersonal skills, must display excellent leadership and people skills, and demonstrate ability to work collaboratively with others in a highly matrixed environment.

+ Must be self-motivated, display scientific curiosity, demonstrated ability to work independently and learn quickly.

+ Must be goal oriented and focused on completing work on time.

+ Thrive in a highly interactive, fast-paced and dynamic team environment and able to quickly adapt to changing priorities.

+ Must be fluent in English both oral and written and possess good communication and presentation skills.

+ Full understanding of laboratory requirements and SOPs.

+ Ability to independently optimize analytical methods.

+ Proven problem solving and troubleshooting abilities.

+ Effective written and oral communication skills

+ Ability to independently review and understand project proposals/plans.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**Other Job Details:**

**Last Date to Apply for Job:** 12/6/17

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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