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Postdoctoral Fellow, Oncology Target Discovery


Pearl River, NY
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Job Details

We are seeking a driven and accomplished postdoctoral fellow to join the Oncology Target Discovery group within the Oncology R&D (WRD) unit of Pfizer's Worldwide R&D (WRD) division in Pearl River, NY. The successful candidate will work on molecular connections between mTORC1 (mechanistic Target of Rapamycin Complex 1) and metabolic networks in the context of cancer. Guided by experienced mentors with strong academic track records, the successful candidate will study fundamental questions in cancer biology with the ultimate goal of publication in major scientific journals. Thus, a strong research experience in biochemistry, cell biology, molecular biology and documented accomplishments including significant publications is required. He/she will be highly self-motivated with a sense of urgency and focus on important problems. While driven to make strong individual contributions, the successful candidate will also enjoy a highly interactive, team-oriented environment and thrive by taking advantage of the significant multi-disciplinary resources available at Pfizer. This will be facilitated by the candidate's excellent communication and interpersonal skills, which complement strong work ethics and overall scientific excellence.

**Role Responsibilities**

Work independently and as part of teams to conceive, design, execute, analyze/interpret, and refine experiments ranging from biochemical and molecular / cellular assays, using in vitro and in vivo model systems.

Specific duties to include:

+ Contribute intellectually and at the bench to the conception, design, execution, analysis, interpretation and internal or external presentation of studies on oncogenic events and cellular metabolism in tumor cells

+ Independently, but with guidance by experienced mentors, develop results into compelling stories for publication in major scientific journals and presentations on major scientific meetings and conferences, both internally and externally

+ Apply genetic and pharmacologic approaches to modulate targets in vitro and in vivo to perform functional studies. This will include CRISPR, RNAi, viral vector delivery, transfection, small molecules and other pharmacologic approaches to modulate targets.

+ Employ computational, metabolomic and proteomic methods.

+ Use electronic data capture/analysis tools such as Excel, GraphPad, Biobook, Spotfire and PowerPoint for experimental documentation and data analysis/presentations.

+ Present research results and methodologies at weekly meetings with immediate supervisor and/or project leader, and at meetings with members of the oncology research unit as appropriate.

+ Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development.


+ Recent Ph.D. in Cell Biology, Molecular Biology, or Biochemistry (or a comparable biological science) with a track record of scientific accomplishment as exemplified by significant scientific publications or within 6 months of graduating

+ Experience with devising and implementing in vitro and in vivo immunological functional assays

+ Experience in cellular metabolism and oncogenic signaling pathways.

+ Ability to work in a team environment; excellent written and oral communication skills in English; strong presentation skills and ability to discuss data at project team meetings.

+ Able to master new concepts and techniques quickly.

+ Strong attention to detail and organizational skills to manage projects in parallel


Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations, ability to read, comprehend and process complex scientific matter, and perform complex data analysis. Ability to travel by air, water and ground.


Ability to accommodate non-standard work schedules due to experimental regimen or travel. Ability to adhere to safe work practices and wear full personal protective equipment. Ability to travel nationally and internationally.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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