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Postdoctoral Fellow, Protein Engineering / In Vivo


South San Francisco, CA
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Job Details

Job Title Postdoctoral Fellow, Protein Engineering / In Vivo

JobID 1039839-1852

Location: South San Francisco, CA

Description *About Pfizer*

A career at Pfizer offers opportunity, ownership and impact.All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

*Role Description*

We have an exciting opportunity for a talented, enthusiastic and independent Postdoctoral Fellow with demonstrated experience in transplant rejection or cancer immunology to work on improving the persistence of allogeneic CAR-T cells.


This Postdoctoral Fellowship will be part of a joint collaboration between the Protein Engineering and Cancer Biology departments. The Protein Engineering department has a strong track record of success in developing world class methods and technologies and using them to generate novel antibody therapeutics, including chimeric antigen receptor (CAR) T cells. CAR-T cells have entered the clinic and have demonstrated very strong potency in the treatment of hematological malignancies. Pfizer is committed to developing allogeneic CAR-T cells in order to provide more patients access to this potentially transformative cancer therapy, but improving their persistence may be paramount to their success and widespread dissemination. Your goal will be to develop protein engineering based solutions to improve the persistence of allogeneic CAR-T cells, and demonstrate their ability to suppress allorejection in vitro and in vivo. The candidate must have a strong background in immunological techniques including in vivo models; further knowledge in transplant rejection or cancer immunology would be a significant advantage.


The ideal candidate will have:* PhD in Immunology, Cancer Biology, or Systems Biology with prior research experience in transplant rejection or cancer immunology is preferred* Highly motivated, independent, with a strong passion and commitment to science * Proven ability to independently design and execute incisive experiments and interpret results * Outstanding communication skills, pro-active attitude, innovative thinking, and strong desire to contribute* Strong track record of publications* Ability and desire to work in an interdisciplinary scientific team and the desire to learn new techniques

*EEO & Employment Eligibility*

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

*Postdoctoral Fellow, Protein Engineering / In Vivo*
*South San Francisco, California*

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