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Principal Scientist, Cancer Immunology


South San Francisco, CA
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Job Details

Job Title Principal Scientist, Cancer Immunology

JobID 1043727-1852

Location: South San Francisco, CA

Description *About Pfizer*

A career at Pfizer offers opportunity, ownership and impact.All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

*Role Description*

The T cell Immuno-Oncology (I-O) group in Pfizer is building a world-class immunology team and is seeking a highly motivated and creative Principal Scientist to join a group of researchers evaluating novel therapies in the fields of Cancer Immunotherapy, Immune Checkpoint Biology, and Innate Immunity. The candidate will report to the Director, Cancer Immunology and work closely with other disciplines across Pfizer to drive early discovery research programs into early clinical development, providing scientific and technical leadership. Specifically, the candidate will identify unique tumor-specific micro-environmental cues that impact T cell function, differentiation and trafficking using a variety of tools including, classic molecular, cellular, and biochemical techniques, as well as modern imaging techniques, systems immunology, bioinformatics, and preclinical in vitro and in vivo models.


*Supervise research associates and/or scientists.*Discover and develop new therapeutic modalities for cancer immunotherapy.*Independently design and perform studies to evaluate the anatomical distribution, persistence and function of antigen-specific T cells in preclinical models of cancer. *Explore disease mechanisms and mechanism of drug action in vitro and in vivo.*Collaborate with protein engineering, computational biology, T cell redirecting therapy group and clinical development group to pursue the most promising drug candidates through clinical trials.*Participate in collaboration on novel I-O targets with internal and external collaborators.*Present at group meetings, global project team meetings, and site meetings.


*Ph.D. in Immunology with 4 years of experience in T cell biology and/or tumor immunology.*Strong understanding of innate and adoptive immune systems.*In-depth understanding of: T cell subsets and surface markers - Teff, Tem, Tcm,Trm, Treg Th1, Th2 etc.Inhibitory and co-stimulatory molecules and their associated signal transduction pathways.*Solid technical knowledge and hands-on experience with conventional immunological techniques.*Broad experience in assessing T cell function, differentiation, and memory development.*Experience in immune cell isolation and characterization using multi-color flow cytometry.*Working knowledge of various murine tumor and/or infectious disease models.*Ability to evaluate and recommend new therapeutic concepts in the area of immune modulation.*Ability to supervise, mentor and develop research associates and scientists.*Pro-active attitude and strong desire to discover novel biology and potential new drugs.*Strong oral presentation and communication skills.*Ability to perform complex data analysis.*Ability to analyze and interpret work published in the field and use it to place our work in context.

*EEO & Employment Eligibility*

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

*Principal Scientist, Cancer Immunology*
*South San Francisco, California*

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