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Principal Scientist, Medicinal Chemistry


Cambridge, MA 02139
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Job Details


The Internal Medicine (IM) Medicinal Chemistry Group delivers scientific excellence in the small molecule medicinal chemistry portfolio aligned to the IM Research Unit (IM RU). This individual will work within the IM Med. Chem. Design Group and be responsible for contributing to the medicinal chemistry effort on 1-2 projects, in collaboration with the IM biology group and IM Med. Chem Synthesis Group.

Delivery of the IM portfolio requires discipline excellence and collaboration with synthetic chemistry to drive appropriate selection of target compounds and speed to FIH. The design chemist is accountable for driving a strong scientific agenda by utilizing available design tools to generate design hypotheses and contribute to target design.

+ Contributes to medicinal chemistry strategy and design tactics to advance the portfolio of the IM RU.

+ Leverages available data and expertise to develop design hypotheses and contribute design ideas, as part of a design team, across 1-2 programs to advance the ESD-CS portfolio of the IM RU.

+ Makes effective use of both internal & external design resources available to the project team.

+ Seeks to deliver project objectives in line with allocated resources under time constraints set in collaboration with the Project Team and IM RU leadership and drive the appropriate selection of target compounds with speed to PoC.

+ Seeks to maintain productivity and competitiveness against internal and external benchmarks.

+ Builds internal/external recognition of the teams and RU through contributing to effective project communication plans.


+ Demonstrates strong learning agility. Comfortable moving into and mastering new or unfamiliar areas of science.

+ Working with local leadership to put in place an active program of self-development in medicinal chemistry design skills

+ Contributes to chemistry strategy aligned with project objectives

+ Data analysis to develop valid design hypotheses

+ Effective use of contemporary design tools, allied to partner design team members with computational and synthesis colleagues, to drive effective target design and prioritization within projects

+ Partnership with enabling functions within Medicine Design, including structural biology, chemical biology, primary pharmacology, and pharmacokinetics & drug metabolism to drive effective target design and lead compound prioritization

+ Partnership with enabling functions within Pfizer, including safety scientists in DSRD to advance projects


Doctoral level degree or equivalent research experience with an exposure to design and synthesis of small molecules, possessing strong interest to learn, or a developing familiarity with, drug design.


The role is located in Cambridge, Mass and will require visits to the Groton Connecticut sites for face to face meetings. The frequency of these visits will be 6-12 times per year.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**Additional Offer Details:**

+ **Last Date to Apply for Job:** September 21, 2017

+ **This job is (Pfizer) (Exempt) (US/PR) Grade:** 011

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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