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Principal Scientist, Multiplex IF/IHC


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Job Details


We are seeking a highly motivated Principal Scientist to drive tissue analysis using state-of-the-art immunohistochemistry and multiplex IF technologies to better understand immune and tumor microenvironment. The candidate will be part of a larger inter-disciplinary team that focuses on target discovery, validation and biomarker research in immune-oncology. The candidate should have the ability to work independently and come up with quick, robust and creative solutions to various research goals.


+ Hands-on IHC single and multiplex assay development and staining, both manual and automated, on pre-clinical, non-clinical and clinical samples

+ Imaging and analysis of tissue sections using automated microscopy, and manual and automated image analysis

+ Execute developed experimental protocols and spearhead novel multiplex IF technologies to address specific biological questions and identify predictive biomarkers in support of clinical pipeline



+ MS or PhD required.

+ At least 8 years of dedicated experience (or MS with 10 years of experience) in microscopy technologies such as confocal/multiphoton microscopy, super-resolution microscopy, light-sheet microscopy, live imaging.

+ The qualified candidate will have the ability to apply a wide range of imaging and image analysis techniques in biological systems, including cell and tissue samples, preferably human tissues

+ Experience in the application of biomarkers towards oncology and immuno-oncology drug development is preferred

+ Ability to work effectively collaborate with multi-disciplinary teams focused on answering key biological questions

+ Excellent communication skills (oral and written) as demonstrated by publications & presentations

+ Ability to multi-task and prioritize projects required

+ Ability to drive projects with minimal supervision and work independently


+ Extensive knowledge in histopathological techniques, including tissue sample preparation, special stains, and collecting images with IHC and IF (minimum 4 fluorescent dyes) staining is required

Experience in image processing and analysis using existing software packages (such as Halo, Definiens, ImageJ), ideally with ability to implement custom image analysis pipelines

The ability to troubleshoot and find quick, robust solutions for histotechnological and immunofluorescence challenges

+ Ability to identify biological problems that can be efficiently addressed through multiplex imaging technologies

+ First authorship manuscripts that demonstrate the application of imaging technologies in high impact journals

+ Provide direction to deliver upon short term goals while driving innovative approaches that shape future strategies

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**Other Job Details:**

+ Eligible for Relocation PackageEligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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