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Principal Scientist, Receptor Biochemist


San Diego, CA
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Job Details

**Role Summary**

The Pfizer Oncology Research & Development group in La Jolla, CA is seeking a full-time employee to support the drug discovery process to create innovative cancer therapies. The successful candidate will provide expert scientific and technical expertise towards the discovery and pre-clinical development of small molecule drugs for receptor-class protein targets (e.g. GPCR, NHR, SLC). The successful candidate will work with a high degree of independence to provide biochemical insight on receptor targets and ligands as well as impact cancer drug discovery project teams at a strategic level.


We are seeking a highly-motivated research scientist to join the Biochemistry & Primary screening group. The researcher will apply their advanced scientific and technical knowledge of cellular receptors such as GPCR and nuclear hormone receptors to the development of small molecule agonists and antagonists for treatment of cancer. The successful candidate will be responsible for the development and operation of assays for the characterization of small molecule-protein and protein-protein interactions. The researcher will work closely with colleagues from other scientific disciplines and will contribute their scientific and technical expertise to help direct and guide decisions on a project team. As an expert in receptor biochemistry and function assays, the scientist will directly contribute to the elucidation of mechanisms of drug action and receptor signaling as part of a team focused on the discovery of new cancer drugs.


+ The ideal candidate must have a Ph.D. in biochemistry or cell biology (or related field) with 4 - 5 years of experience in drug discovery.

+ The individual will be a technical expert with cellular receptors (e.g. GPCR, NHR) and well experienced in methods to characterize agonists and antagonists and their biochemical and cellular function/activities.

+ Experience in the development of robust, functional in vitro assays for the discovery of small molecule agonist/antagonists of membrane receptors is required.

+ Corresponding or senior-authored publications in top-tier journals is also a prerequisite.

+ The candidate must have good communication skills and be capable of working independently and as part of an effective, multi-disciplined team.

**Additional Offer Details:**

+ Grade: 11

+ Eligible for Relocation Package

+ Eligible for Employee Referral Bonus

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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