Sign In
 [New User? Sign Up]
Mobile Version

Principle Scientist, Global Investigative Toxicology

Pfizer


Location:
Groton, CT
Date:
11/02/2017
2017-11-022017-12-03
Pfizer
Apply on the Company Site
  •  
  • Save Ad
  • Email Friend
  • Print
  • Research Salary

Job Details

We are seeking a highly motivated and accomplished laboratory scientist/investigator to join our nonclinical research team in Global Investigative Toxicology/Drug Safety Research and Development (DSRD). The primary responsibility of Global Investigative Toxicology is to design and carry out investigative studies to position toxicity findings for molecules in preclinical and clinical development. These efforts include hypothesis-driven mechanistic studies and the development of novel in vitro models. We are seeking a research scientist with expertise in the rapidly evolving areas of 2D and 3D in vitro co-cultures, organoids (such as CNS, liver, kidney or gut), stem cell-derived model systems (iPSC) and/or microphysiological (MPS) models (e.g., fluidics-enabled organ on a chip) to enable the development of more physiologically relevant in vitro assays to improve safety assessment of novel therapeutic molecules.







ROLE RESPONSIBILITIES:



Reports to a Director/ Senior Director of Global Investigative Toxicology



Provides scientific expertise in the areas of cell culture, 2D and 3D co-cultures, organoid generation and characterization, development and utilization of iPSCs and MPS models



Develops novel in vitro methods that can be used to address toxicity findings/screen subsequent molecules to eliminate toxicity



Generates high quality laboratory-based investigative data to support portfolio progression and/or mechanistic understanding of toxicity findings



Analyses, documents and reports laboratory data in accordance with company standards and procedures



Effectively communicates experimental findings in both oral and written formats



Functions collaboratively as part of a global multi-disciplinary team







QUALIFICATIONS



PhD degree in Pharmacology, Toxicology, Molecular Biology, Bioengineering, or a related field; Post-doctoral experience highly desirable



Expertise in organ toxicity such as gut, liver, CNS and/or kidney



Prior experience with tissue culture (in particular, primary cultures), iPSC- and MPS-based 3D in vitro models, complex microtissues and organoids



A track record of publication and scientific presentations (e.g., abstracts, posters, podium presentations) related to 3D, iPSC- and MPS-based science.



Knowledge of endpoint assays such as biochemical assays, PCR, western blotting, IHC, flow cytometry, basic high content imaging







Additional Details:







+ Eligible for Employee Referral Bonus



+ Pfizer US Exempt Grade 11







**EEO & Employment Eligibility**



Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.







**Sunshine Act**



Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.







Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
Apply on the Company Site
Powered ByLogo

Featured Jobs[ View All ]

Featured Employers [ View All ]