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Scientist, Transgenic Model

Pfizer


Location:
Andover, MA
Date:
09/19/2017
2017-09-192017-10-18
Job Code:
1611935
Pfizer
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Job Details

Job Title Scientist, Transgenic Model

JobID 1611935

Location: Andover, MA

Description Pfizer is increasingly relying on human genetics to inform the discovery and validation of new drug targets and the mechanistic understanding of disease pathology. A necessary component of testing potential targets arising from any source is assessment of functional consequences of candidate variants or genes in rodent models, to determine physiological effect and tractability to drug discovery. A small unit is forming to respond to the need for validation of targets, through rapid generation of transgenic mice. The Microinjectionist will work in this group and be responsible for technical creation of models by injection of CRISPR constructs, and for participating in animal breeding with support of two dedicated husbandry experts from Comparative Medicine. The unit will partner with colleagues responsible for in vitro functional genomics to develop overall strategies for testing and prioritizing nominated targets in key disease areas and will be responsible for testing and applying the latest technical developments in gene editing and transgenic model creation. This is a unique opportunity to play an integral role in executing the strategy of one of the world's leading developers of novel therapeutics.



**MAIN RESPONSIBILITIES**



+ Skilled in technical aspects of cell culture, microinjection, implantation, working with CRISPR constructs, breeding of animals, and other aspects of generation of genetically engineered model mice.

+ Able to support the initiation of estimated up to fifty model lines per year.

+ Develop and apply systems for efficient project tracking and management and throughput.

+ Support the testing of new and experimental technologies for creation of animal models, together with other members of the group.

+ Coordinate with Comparative Medicine for colony expansion.

+ Rigorous compliance with the letter and spirit of all animal welfare and safety protocols.



**BASIC QUALIFICATIONS**



+ Bachelor's degree in biology or related field with 2-4 years of experience, or Master's degree in biology with 0-2 years of experience.

+ Demonstrated expert in microinjection and cell culture with good understanding of all the scientific and practical steps involved in making transgenic models.

+ Ability to engage closely in multiple projects local and remote and to track record of timely execution.

+ Excellent interpersonal and communication skills; ability to maintain productive and congenial collaborations in a fast-paced environment.

+ Devotion to advancing team goals and enthusiasm for contributing to the mission of drug discovery.

+ Able to spend significant time at microscope.

+ Ability to work with laboratory rodents.



**PREFERRED QUALIFICATIONS**



+ 5 years of experience, preferably but not necessarily including experience in the pharmaceutical or biotechnology industry, in a range of functional genomic technologies; solid understanding of bioinformatics tools and computational biology opportunities.



**Additional Offer Details**



+ **Last Date to Apply for Job: November 7, 2017**

+ **Grade: 007**

+ Eligible for Employee Referral Bonus

+ Locations: Andover MA, Groton CT, Pearl River NY



**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

A career at Pfizer offers opportunity, ownership and impact.



All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.



Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.


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