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Senior Associate Scientist, In Vitro Pharmacology Assay Development


Cambridge, MA
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Job Details

Job Title Senior Associate Scientist, In Vitro Pharmacology Assay Development

JobID 1611337

Location: Cambridge, MA

Description The Internal Medicine Research Unit (IMRU) is seeking a highly motivated laboratory scientist to be a member of the in vitro pharmacology/assay development group. This Senior Associate Scientist will be an integral member of a team which broadly supports the IMRU portfolio across all the disease areas of interest. The individual will apply a scientific background in in vitro pharmacology to develop primary assays for carrying out SAR (structure-activity relationships) and design/execute experiments for understanding the mechanism of action of compounds throughout different stages of the project. In this position, the successful candidate will work within a large matrix environment, across a portfolio of programs, collaborating with multiple groups including discovery biology and several partner lines including medicinal chemistry and the central primary pharmacology group.


+ Perform laboratory experiments to establish robust biochemical and cell-based compound screening assays across a broad array of target classes for Neurodegeneration and Metabolism project teams

+ Maintain immortalized cell, primary cell and iPS cell cultures as needed for assay development and low volume screening efforts

+ Collaborate with the Primary Pharmacology Group to ensure alignment around assay technology selection, assay quality criteria and validation requirements

+ Operate a broad array of liquid-handling and plate-based pharmacology equipment to ensure efficient automated workflows for newly developed assays

+ Ensure efficient assay transfer to Primary Pharmacology Group or external screening vendors

+ Prepare and present experimental results to project teams

+ Maintain high quality experimental records within electronic laboratory notebook


BA, BS or Masters in biology, pharmacology, biochemistry or a related field with at least 2 years of laboratory experience relevant to this position.

+ Broad understanding of biology, preferably with an emphasis in neuroscience and/or metabolism

+ Scientific understanding of the major target classes (GPCRs, Enzymes, transporters, ion channels, etc.)

+ Experience with assay development methodologies

+ Experience with cell culture (primary and immortalized)

+ Experience in low to moderate throughput compound screening preferred but not mandatory

+ Experience with automation of liquid handling and screening workflows preferred but not mandatory

+ Ability to conduct data analysis using Microsoft Excel, GraphPad Prism, or equivalent software.

+ Ability to complete experiments and present results in individual and group settings.

+ Ability to work on multiple programs simultaneously and be an integral member of cross-functional project teams

+ Proven verbal and written communication skills, and the ability to work in a collaborative team environment

**Additional Offer Details**

+ **Last Date to Apply for Job: October 18, 2017**

+ **Grade: 004**

+ **Location: Cambridge, MA (Kendall Square)**

+ **Eligible for Employee Referral Bonus**

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

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