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Senior Associate Scientist, Translational Gene Therapy AAV Biology


Cambridge, MA
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Job Details

The Gene Therapy Translational Research group is part of Pfizer's Rare Disease Research Unit (RDRU) focused on gene therapy specific platform technologies towards the delivery of IND-approved vectors for testing in clinical trials. This Senior Associate Scientist will be part of an interdisciplinary team partnering closely with the RDRU Biology and Gene Therapy groups as well as colleagues in other Pfizer disciplines contributing to translational preclinical packages related to novel gene therapies. This bench Senior Associate Scientist will be part of an interdisciplinary team and contribute to preclinical data required to advance Pfizer's gene therapy-based portfolio. The Senior Associate Scientist will perform AAV cell based assays, including potency, RC AAV, TCID50, NAB, and other assays. The Senior Associate Scientist will have a deep knowledge of AAV vector biology, be able to work independently, use scientific judgment in making decisions within the area of technical expertize, propose new options and develop new processes.


Perform cell based assays related to characterization of the AAV gene therapy vectors. Including vector design and cassette optimization. Assays include RC AAV, TCID50, potency, NAB, ELISA, ELISPOT, ICCS and other cell based assays

Design and clone in vivo expression vectors. Design, execute and troubleshoot assays. Create master cell banks, maintain cell inventory.

Partner with colleagues working on Gene Therapy projects, e.g. RDRU Biology, I&I RU and IMRU colleagues, PDM, PharmSci, CDX and CAG colleagues.

Independently d eliver high-value data and lead in vivo aspects of AAV-based gene therapy projects in the RDRU pipeline.

Evaluate and engage external collaborators and Contract Research Laboratories (CROs).


Recent Bachelors with 2-4 years experience or Masters Degree in the life sciences with 2+ year's relevant experience

Scientific training in cloning, fluorescent microscopy, cell based assays and cell banking

Prior expertise with AAV characterization assays is required

Hands on lab experience required

Evidence of scientific accomplishments in the form of publications and presentations.

Exceptional communication skills and demonstrated ability to work effectively as part of a team.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**Other Job Details:**

+ **Last Date to Apply for Job: March 9, 2018**

+ Eligible for Relocation Package

+ Eligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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