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Senior Principal Scientist, ImmunoPharmacology Tumor Biology


San Diego, CA
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Job Details

This position will provide overall experimental strategy and direction in developing study campaigns that measure and characterize the efficacy of immunotherapeutic platforms and in combination with immuno-oncology agents when tested in fit for purpose murine tumor models. The position will apply expertise in tumor biology models, immuno-oncology related models, and translational research to understand/refine the mechanism of action responsible for preclinical efficacy of cancer vaccines and similar immunotherapeutic approaches and evaluate their effects on tumor progression, on the functions of the adaptive immune system, the modulation of the tumor microenvironment, and the impact on immune cell subsets. The position will also work closely with the CVIT Immunology and Translational Immuno-oncology groups as well as the Pfizer Oncology Research Department.

**Tumor Biology Research**

+ Apply expertise in tumor biology models, immuno-oncology related models, and translational research to understand/refine the mechanism of action responsible for preclinical efficacy of cancer vaccines and similar immunotherapeutic approaches.

+ Evaluate the in vivo effects of our experimental immunotherapeutic platforms on tumor progression, on the functions of the adaptive immune system and the tumor microenvironment, and the impact of our therapeutic approaches on immune cell subsets.

**Primary Responsibilities - Laboratory based (~40% of time)**

+ Design, develop, characterize, implement and validate relevant in vivo immuno-oncology-related models, e.g., syngeneic subcutaneous, orthotopic spontaneous tumor models, xenograft models including models derived from primary patient samples, for identifying and profiling the pharmacologic and immunologic effects of our immunotherapeutic platforms.

+ Demonstrated experience in independently designing and executing experiments focused on understanding the immunologic mechanisms that modulate the adaptive immune response against tumor antigens.

+ Investigate the tumor microenvironment and the causality of therapeutic approaches in overcoming the immunosuppressive microenvironment.

+ Co-lead the preclinical research that provides the rationale for immuno-modulator combinations.

**Group Lead Effectiveness**

+ Manages the day-to-day workload of one or more direct reports.

+ Sets appropriate and impactful goals for colleagues, provides honest feedback on progress towards goals, conducts fair and reasoned annual performance appraisals.

+ In partnership with colleagues agrees to manage realistic and achievable individual development plans.

+ Confronts and manages difficult situations and practices conflict management.

+ Working with project teams defines study aims and experimental plans that meet the objectives of the research plan

+ Coordinates the scheduling of study readouts with project teams, ImmunoPharmacology, Immunology and Translational Immuno-oncology groups.

+ Organizes and leads study teams on readouts and coordinates both the in vivo vivarium and ex vivo laboratory work

+ Manages the generation of data, expertly analyzes and interprets experimental data ensuring its accuracy, and delivers such to the project in a timely manner.

+ Regularly records experimental work upon completion in electronic notebook systems and archives instrument raw data on server databases.

+ Builds the capacity/functionality of the Tumor Biology group ensuring the latest methodology/ technology is considered and adopted as necessary

**Leadership & Communication**

+ Takes a position in controversial issues when appropriate and skillfully challenges the team to reach high-quality decisions that are in the best interests of the project.

+ Communicates effectively with CVIT senior management and beyond.

+ Actively contributes ideas and challenges data at project reviews, line and project team meetings.

+ Provides clear, concise and timely responses to project team requests for data and experimental information.

**Scientific/ Technical Knowledge**

+ Recognized SME in tumor biology models. Understands the application of fit for purpose in vivo models and the translatability of such data to the clinic.

+ Understands the preclinical immune-oncology development process, applies appropriate rigor to experimental design, uses contemporary standard of care for test comparison, and assimilates new and emerging information from the literature and applies to ongoing or future studies.


+ PhD in life sciences, with a focus on immunology and/or oncology.

+ 7+ years (beyond post-doc) of experience working in a laboratory setting that routinely performs in vivo and ex vivo tumor biology experiments. Additionally, has similar and deep experience working with tumor models to characterize adaptive immune responses.Extensive practical experience with tumor and immune-oncology mouse models (syngeneic, genetically engineered or humanized) testing various immuno-oncology agents and biological delivery platforms such DNA, RNA and virus

+ Recognized expert (publications and job experience) in planning in vivo and ex vivo tumor biology experiments that assess efficacy outcomes of experimental therapies.

+ Solid experience in working with models that characterize adaptive immune responses especially in the tumor microenvironment.

+ Practical understanding and application of statistical methods to experimental design and outcome measures.

+ Good oral and written communication skills

+ Successful experience in interacting with and influencing thought leaders, including the development and rationalization of research strategies.

+ Has demonstrated the ability to have a positive impact on others

+ Effective in communication skills both verbal and written; listens and understands well. Excellent interactive skills with people with diverse backgrounds and perspectives.

+ Proactively recognizes needs and problems, and independently identifies and implements effective steps and solutions.

**Physical/Mental Requirements**

+ Standing, sitting, bending, lifting, walking in a laboratory or vivarium setting.

+ Use of Personal Protective Equipment (PPE) in a BSL-2 laboratory; additional PPE requirements when working in vivarium barrier suites.

+ Standard business office conditions; sitting, standing as appropriate

+ Infrequent travel (generally other Pfizer sites or professional meetings)

**Non-Standard Work Schedule, Travel or Environment Requirements**

+ Lifting, sitting, standing, walking, bending, repetitive pipetting, ability to perform mathematical calculations, ability to read, understand, and perform written protocols, and ability to perform moderately complex data analysis using Microsoft Excel, GraphPad Prism or other similar data analysis software.

+ Occasional off-hour and weekend schedule.

Other requirements:

+ Adherence to La Jolla EHS policies and training; ability to work with human, non-human primate or murine blood samples and organ tissues.

+ Will be required to work with BSL2 infectious viruses (e.g. Vaccinia virus, adenovirus, and influenza) and must receive and maintain required vaccinations or provide satisfactory proof of same.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**Other Job Details**

+ Eligible for Relocation Package

+ Eligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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