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Senior Principal Scientist, Rare Disease, Skeletal and Cardiac Muscle

Pfizer


Location:
Cambridge, MA
Date:
11/14/2017
2017-11-142017-12-15
Pfizer
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Job Details

As part of an industry-leading Rare Disease Research Unit (RDRU), this role will support the rare skeletal and cardiac muscle disease early portfolio projects by driving target identification, assay development and compound screening for drug candidates to test in clinical trials for rare skeletal muscle and heart diseases such as Duchenne Muscular Dystrophy (DMD).







**ROLE RESPONSIBILITIES**







+ Reports into Sr Director who manages the rare skeletal and cardiac muscle disease drug development portfolio in the RDRU



+ Leads in vitro assay development needs for skeletal and cardiac muscle disease projects, managing at least 1 lab-based scientist and acting as biology lead for cross functional project teams



+ Demonstrates innovative thinking to meet in vitro screening needs, including use of iPSCs and 3D tissue structures



+ Utilizing historical knowledge in the field of rare muscle disease to prosecute external opportunities and supporting due diligence efforts



+ Drive publication strategies for the unit







**QUALIFICATIONS**



**Required**







+ PhD in Physiology/Pharmacology/Biological/Biochemical Sciences or other related discipline



+ 5+ years experience working in a Biopharmaceutical company developing drug development candidates in the preclinical space



+ Knowledge of and experience working with skeletal and cardiac muscle cells and tissues



+ Evidence of experience in developing assays for target identification and screening



+ Demonstrated aptitude for independent research and innovative thinking



+ Experienced supervisor of lab-based scientists



+ Demonstrated ability to lead matrixed project teams



+ Ability to present clear and compelling scientific arguments







**Preferred**







+ Knowledge and experience with cell-based and animal models of DMD considered a plus



+ Experienced in assay development, screening and hit to lead activities with different modalities (small molecule, biologic and gene therapy)







**Organizational Relationships.**



Reporting to the Sr Director of the Rare Skeletal & Cardiac Muscle Biology group, the candidate will supervise initially at least one lab-based scientist working to develop assays and analytical tools for DMD skeletal and cardiac muscle target ID and hit to lead screens. These projects will require interactions with Medicinal Chemists and Protein Engineers pending the modality being developed (small molecule or biologic). Also, interactions with RDRU assay development scientists to include peers working to develop similar screens. The candidate will also liaise with External Science & Innovation colleagues to assist in the prosecution of external opportunities which may assist with project needs.



Supervise at least one direct report (lab-based scientist).







**EEO & Employment Eligibility**



Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.







**Sunshine Act**



Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.







**Additional Offer Details:**







+ **Last Date to Apply for Job:** December 1, 2017



+ **Grade:** 013



+ Eligible for Employee Referral Bonus: yes







Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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