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Senior Scientist, AAV Rare Disease


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Job Details

The Rare Diseases Research Unit (RDRU) of Pfizer is committed to the development of new therapies to address unmet medical needs of those individuals with rare and neglected diseases and to make a real impact on patient lives.

This is a really exciting time for Pfizer RDRU, which has recently established Bamboo Therapeutics in Chapel Hill, NC. Our laboratory is dedicated to the discovery and development of Gene Therapy based products and our commitment to rare disease research and to genetic medicine development is expected to be an area of tremendous growth in the coming years. Bamboo is fitted with state-of-the art laboratories and equipment, providing the perfect environment for cutting-edge science and exciting projects

This individual will be working closely with fellow R&D scientists to manufacture research grade plasmid DNA and AAV viral vectors to support AAV candidate selection for future gene therapy applications.

This position offers a challenging and exciting opportunity for implementing and learning different microbial and mammalian cell culture techniques and to solve complex biological problems. It also brings a unique chance to collaborate with talented and dedicated colleagues across the world while developing and expanding your career. The ideal candidate is a highly talented and self-motivated individual with a strong scientific background.

The role will be part of a small, but expanding team, that will have the responsibility for manufacturing research grade AAV-based gene therapy vectors to support early product development and AAV candidate selection. The role will involve working with equipment necessary for small scale production of various AAV vectors and DNA plasmids. The individual must be able to conduct work with a quality mindset.


+ Serve as a senior scientist for research grade DNA plasmid and AAV vector manufacturing who reports directly to the Principal Scientist overseeing multiple projects

+ Manufacturing of AAV or other viral vectors for the purpose of aiding in the AAV candidate selection process for gene therapy programs.

+ Manage team of colleagues manufacturing AAV vectors to support R&D experimentation using stir tank bioreactors, transfection, filtration, centrifugation, and chromatography techniques.

+ Work with Principal Scientist and relevant teams to implement and carry out project plans and meet timelines to support the early development of gene therapy programs

+ Ensure high quality core support for projects.

+ Ensure manufacturing supplies and reagents are available for use when needed

+ Must ensure detailed lab notebooks are part of daily activities

+ Support internal and external collaboration; through direct interactions, data analysis, and work plan alignment.

+ Maintain laboratory in accordance with GLP-like practices.

+ Establish SOP's specific to the manufacturing job roles and activities to ensure consistency.

+ Understand and follow various Pfizer guidelines.


+ PhD with relevant laboratory experience or equivalent experience in Biological Sciences, Biochemical engineering or a related fields with 0-3 years of experience in a similar capacity

+ Extensive experience in AAV vector manufacturing is essential.

+ Extensive experience in the culture of mammalian cell lines and microbial cells either in adherent or suspension system is essential

+ Prior work with WAVE and stir tank bioreactors and downstream process equipment is essential

+ Prior experience in small scale cell culture is essential

+ Experience with a variety of basic molecular biology techniques, such as cloning, western blots/Elisa, assay development etc would be advantageous

+ Understanding CL2 safety requirements, practice of good sterile techniques, and prior work experience with viruses and mammalian cells including HEK293, is essential

+ Ability to develop and follow detailed SOPs

+ Demonstrated history of successful troubleshooting and experimental design

+ Experience managing subordinates

+ Excellent communication and interpersonal skills.

+ Ability to assemble and communicate scientific data

**Other Job Details:**

+ **Last Date to Apply for Job: April 9, 2018**

+ Additional Location Information: Durham, NC

+ Eligible for Employee Referral Bonus: Yes

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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