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Senior Scientist, Cancer Immuno

Pfizer


Location:
San Diego, CA
Date:
03/24/2017
Job Code:
1044007-1852
Pfizer
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Job Details

Job Title Senior Scientist, Cancer Immuno

JobID 1044007-1852

Location: San Diego, CA

Description *About Pfizer*

A career at Pfizer offers opportunity, ownership and impact.All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.



*Role Description*

We seek a driven and accomplished immuno-oncologist at the senior scientist level to join our Cancer Immuno-pharmacology (CIP) group in the Oncology Research & Development unit (ORD) of Pfizer's Worldwide R&D (WRD) division in La Jolla, California.Participate in pre-clinical drug discovery and development projects in immuno-oncology,focusing on small molecules alone or in combination with biologics. Work in one of the areas T and NK cell biology, myeloid cell biology, immunosuppressive mechanisms in the tumor microenvironment, reprogramming of suppressive immune cells, tumor immunogenicity and antigen presentation, or tumor barrier mechanisms. In collaboration with partner lines, contribute experimentally and scientifically to target identification, prioritization and validation, drug discovery and drug development. Employ cutting-edge in vitro and in vivo animal and human cancer models. Complement the existing CIP group and provide immunology expertise to ORD and WRD.Organizational Relationships:Internal: Entire ORU group, including supervisors, peers and reports. Partner lines includingPDM, DSRD, TRG, OBU, OTD, CTI, TCB, BDD, Rinat, Vaccine Group, TranslationalOncology.External: iTeos, CROs including WuXi, HDB, Crown Bio and others. Various vendors.



*Responsibilities*

* Work with a principal or senior principal scientist to develop novel small molecule cancer immunotherapeutics.* Provide expertise in one of the areas T and NK cell biology, myeloid cell biology, immunosuppressive mechanisms in the tumor microenvironment, reprogramming of suppressive immune cells, tumor immunogenicity and antigen presentation, or tumor barrier mechanisms.* Collaborate with Pfizer's world-class chemical biology and functional genomics groups toidentify novel mechanisms and targets limiting anti-tumor immune responses.* Design and conduct relevant in vitro and in vivo assays and models, with particular emphasis on humanized systems. Use them to validate and prioritize targets for improving anti-tumor immune responses, and to discover and develop target-modulating compounds.* Contribute experimentally and scientifically to all stages of pre-clinical drug discovery and development.* Design, conduct, and guide experiments. Generate, evaluate and present data. Participate actively in due-diligence analyses, meeting reports, project team, governance and other meetings and journal clubs.* Train colleagues in technical and scientific aspects of immuno-oncology.* Conduct lab management activities, including equipment maintenance, ordering and lab organization.* Interact productively with internal and external groups, cross-functional teams and initiatives.



*Qualifications*

Education and Experience:* Ph.D. or M.D. in immunology with 1-3 yrs' experience in immunology, or a related discipline with postdoctoral experience in immuno-oncology or immunology evidenced by strong publications.* At least 3 years of specific experience in cancer immunology.* Strong publication record or equivalent achievements in industry.Technical Skill Requirements:* Proven ability to make important scientific contributions to immuno-oncology.* Ability to stay on top of novel scientific developments and opportunities, and to identify andquickly enter relevant new fields to make significant contributions.* Strong expertise in one of the areas T and NK cell biology, myeloid cell biology,immunosuppressive mechanisms in the tumor microenvironment, reprogramming of suppressive immune cells, tumor immunogenicity and antigen presentation, or tumor barrier mechanisms.* Strong experience with in vitro and in vivo models of the tumor microenvironment, inparticular in modulating Treg cells, MDSC or M2 macrophages, in augmenting tumorantigenicity, or in disrupting tumor barriers to improve immune cell entry.* Proficiency in target identification, validation and mechanistic analysis.* Ability to use multidisciplinary tumor immuno-phenotyping approaches for treatmentoptimization, target discovery and validation.* An ideal candidate has strong experience with human tissue culture systems (co-culture,histoculture, organoids, organ-on-a-chip) and/or humanized mice.* Excellent written and oral communication and presentation skills in English. Proficiency in allcommon office and scientific software.* Strong ability to multi-task and work efficiently and productively in a fast-paced, highlycollaborative, matrixed and diverse team environment. Capacity to contribute to a vivid andchallenging intellectual environment.Physical/Mental Requirements:Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations, abilityto read, comprehend and process complex scientific matter, and to perform complex dataanalysis. Ability to travel by air, water and ground.Non-standard Work Schedule, Travel:Ability to accommodate non-standard work schedules due to experimental regimen or travel.Ability to adhere to safe work practices and wear full personal protective equipment. Ability totravel nationally and internationally.



*EEO & Employment Eligibility*

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.





*Senior Scientist, Cancer Immuno*
*San Diego,California*
*1044007-1852*


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