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Senior Scientist, Cancer Immunology


South San Francisco, CA 94080
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Job Details

**Role Summary**

We are seeking a highly motivated and creative candidate with a strong background in tumor immunology and T cell biology for a Senior Scientist role with the T cell Immuno-Oncology (I-O) Group in Pfizer. The successful candidate will have an opportunity to pursue their own immuno-oncology research project working with a group of researchers evaluating novel cancer immunotherapies, immune checkpoint biology, and innate immunity. Specifically, the candidate will provide immuno-oncology expertise, identifying unique tumor-specific micro-environmental cues that impact T cell differentiation, trafficking, and function using a variety of tools including, classic molecular, cellular, and biochemical techniques, as well as modern imaging techniques, systems immunology, bioinformatics, and preclinical in vitro and in vivo models. Additionally, the candidate will work closely with other disciplines across Pfizer to drive early discovery research programs into early clinical development.

**Role Responsibilities**

+ Independently design and rigorously execute studies to discover and develop new therapeutic modalities for cancer immunotherapy.

+ Evaluate the anatomical distribution, persistence, and function of tumor antigen-specific T cells in preclinical models of cancer.

+ Explore disease mechanisms and mechanisms of drug action in vitro and in vivo .

+ Collaborate with protein engineering, computational biology, T cell redirecting therapy group and clinical development group to pursue the most promising drug candidates through clinical trials.

+ Participate in collaboration on novel I-O targets with internal and external collaborators.

+ Actively participate in and present data at group meetings, global project team meetings, and site meetings.


+ Ph.D. in Immunology with 1-2 years of experience in T cell biology and/or tumor immunology.

+ Strong understanding of innate and adoptive immune systems.

+ In-depth understanding of:

-T cell subsets and surface markers - Teff, Tem, Tcm, Trm, Treg, Th1, Th2 etc.

-Inhibitory and co-stimulatory molecules and their associated signal transduction pathways.

+ Solid technical knowledge and hands-on experience with conventional immunological techniques.

+ Broad experience in assessing T cell function, differentiation, and memory development.

+ Experience in immune cell isolation and characterization using multi-color flow cytometry.

+ Working knowledge of various murine tumor and/or infectious disease models.

+ Ability to evaluate and recommend new therapeutic concepts in the area of immune modulation.

+ Pro-active attitude and strong desire to discover novel biology and potential new drugs.

+ Strong oral presentation and communication skills.

**Physical/Mental Requirements**

+ Ability to perform complex data analysis

+ Ability to analyze and interpret work published in the field and use it to place our work in context

**Other Job Details**

+ E ligible for Employee Referral Bonus

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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