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Senior Scientist, Cancer Immunotherapy


South San Francisco, CA 94080
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Job Details

We are seeking a highly motivated Senior Scientist with experience in oncology or immunology to join the cancer immunotherapy group and contribute to our ongoing efforts in the discovery and development of immune-oncology agents. The candidate must have the flexibility to work in a fast-paced and highly collaborative environment. S/He is expected to conduct bench work, keep up with relevant research field, and move drug development via interactions with cross-function groups.

**Role Responsibilities:**

+ Design and execute in vitro cell line or primary cell based experiments and optimize the assays for antibody drug candidate screening.

+ Be able to adapt and develop new assays required for drug candidate activity assessment.

+ Design and execute mechanism of action study using animal models or ex vivo methods.

+ Analyze data, draw conclusions, and troubleshoot results independently.

+ Record experimental protocols/results in detail and write technical reports for regulatory filings.

+ Be able to present data and communicate research results among the team.

+ Attend team meetings and deliver well-prepared presentations and is expected to be an active participant in discussions.

**Education and Experience:**

+ PhD with 1+ year research experience in an academic or industrial setting.

+ Prior experience in the fields of immune-oncology, cancer biology, and/or immunology highly preferred.

+ Minimum of 3-5 years' hands on experience in primary cell culture, in vitro or ex vivo immune cell functional assays.

**Technical requirement:**

+ Hands-on working experience with human PBMC, mammalian cell culture, animal primary cell isolation and ex vivo differentiation, followed by multi-color flow-cytometry, ELISA, Luminex based analysis is required.

+ Technical expertise with immune cell-based functional assays (e.g. activation, differentiation, proliferation, and suppression assays by using monocyte/ macrophages, T-cells, or dendritic cells) is highly desired.

+ Proficiency in multi-color flow cytometry, cell sorting, Luminex analysis is required.

+ Experience with basic animal handling and relevant work including dosing (intraperatoneal), bleeding, health monitor, and tissue harvest is a plus.

+ Ability to use appropriate software to perform analysis of data is required (FlowJo, CyTOF, Excel, GraphPad Prism).

+ Must have excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic.

**Other Job Details:**

+ Additional Location Information: South San Francisco, CA

+ Eligible for Employee Referral Bonus

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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