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Senior Scientist: CAR T Cell Biology and Engineering

Pfizer


Location:
South San Francisco, CA
Date:
03/24/2017
Job Code:
1048238-1852
Pfizer
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Job Details

Job Title Senior Scientist: CAR T Cell Biology and Engineering

JobID 1048238-1852

Location: South San Francisco, CA

Description *About Pfizer*

A career at Pfizer offers opportunity, ownership and impact.All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.



*Role Description*

We are seeking to hire an energetic and collaborative scientist with demonstrated expertise in cellular therapies, cell engineering, and/or T cell immunology to join our team and contribute to exciting research on Chimeric Antigen Receptor (CAR) T cells.



*Responsibilities*

*Contribute to the overall advancement and success of our allogeneic CAR T research program.*Engineer, culture, and characterize CAR T cells in vitro to support in vivo mouse studies.*Interact with research, process development, and analytical teams to optimize allogeneic CAR T cell production.*Investigate and implement cutting-edge technologies to optimize CAR T cell engineering and enhance CAR T cell immunophenotype.*Stay up-to-date on the latest scientific literature relevant to cellular therapies, cell engineering, and T cell biology.*Organize, interpret, and present results in small and large group meetings.*Contribute to a dynamic, exciting culture that embraces teamwork and innovation.



*Qualifications*

Education and experience*B.S. degree with 10 years of experience, M.S. degree with 7 years of experience, or Ph.D. with 0 years of experience. Degree in biology-related field required; degree in immunology highly preferred.*Prior experience with cellular therapies, cell engineering, and/or in the field of immunology highly preferred.*Prior experience in industry preferred.Preferred technical skills*Isolation of PBMC from buffy coats/leuko paks*Isolation of T cells from PBMC using MACS/automated cell isolation techniques*Stimulation, culture, and expansion of primary T cells*Generation of retroviral/lentiviral vectors and transduction*Use of gene-editing technologies such as CRISPR-Cas9 and/or TALENs*Multicolor flow cytometry*Intracellular cytokine staining and Cytometric Bead Array*ELISA and Luminex*Proliferation and cytotoxicity assays*DNA and RNA extraction*qRT-PCR*Proficiency in the use of software to support data analysis such as FlowJo, FACSDiva, GraphPad Prism, as well as Microsoft Office (Excel, PowerPoint, Word, Outlook)*Proven ability to: work and think independently and creatively; design a well-controlled experiment; analyze results with a keen, critical mind; organize results and generate presentations; present results in small and large group meetings in a clear and organized manner; be an affable and energetic colleague and team player.PHYSICAL/MENTAL REQUIREMENTS Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations, and ability to perform complex data analysis.



*EEO & Employment Eligibility*

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.





*Senior Scientist: CAR T Cell Biology and Engineering*
*South San Francisco, California*
*1048238-1852*


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