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Senior Scientist, Endogenous Antibody Discovery

Pfizer


Location:
Cambridge, MA
Date:
09/19/2017
2017-09-192017-10-18
Job Code:
1612045
Pfizer
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Job Details

Job Title Senior Scientist, Endogenous Antibody Discovery

JobID 1612045

Location: Cambridge, MA

Description BioMedicine Design's Endogenous Antibody Discovery Group is seeking a Senior Scientist to drive antibody discovery campaigns. The candidate will be primarily responsible for designing and implementing strategies to generate lead antibody candidates by immunizations and hybridoma generation in a high throughput environment. The role also requires a significant contribution to technology development in the area of antibody discovery. The selected candidate will work in close coordination with BioMedicine Design's High Throughput Assay Screening group in lead identification. The successful candidate will have a demonstrated track record in the following areas:



+ Biotherapeutic lead selection with cell based methods (such as Hybridoma generation)

+ Experience with antibody discovery from primary B cells, including antibody isolation with in vitro methods and B cell repertoire analysis using Next Generation Sequencing

+ Dosing of rodents, including rats and mice

+ Evaluation of immune titers by ELISA, flow cytometry and immunofluorescence-based microscopy

+ Use of integrated lab automation

+ Antibody VH-VL molecular cloning

+ Evaluation of novel antibody discovery platforms



Role responsibilities:



+ Design and implementation of immunization strategies

+ Evaluation of immune responses by protein, cell-based and molecular methods

+ Generation and screening of antibodies using cell-based methods in a high-throughput environment

+ Evaluation of new technology platforms for antibody discovery

+ Preparation and delivery of detailed presentations, both written and verbal, to project teams

+ Effective communication and coordination of work in highly matrixed project team environment



Background in Immunology or Molecular Biology specifically with experience in B cell biology. Experience in an industry-like setting preferred. Experience with Biotherapeutic lead generation through cell-based methods, B cell repertoire analysis using Next Generation Sequencing and molecular biology, antibody cloning, and use of integrated laboratory automation desirable. Experience with protein and cell-based screening methods strongly preferred. Experience in the development of novel antibody platforms preferred.



**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.



**Additional Offer Details:**



+ **Last Date to Apply for Job:** October 15, 2017

+ **This job is (Pfizer) (Exempt) (US/PR) Grade:** 008

+ Eligible for Relocation Package: no

+ Eligible for Employee Referral Bonus: yes



A career at Pfizer offers opportunity, ownership and impact.



All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.



Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.


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