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Senior Scientist, Formulation Design and Development

Pfizer


Location:
Groton, CT
Date:
11/13/2017
2017-11-132017-12-14
Pfizer
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Job Details

This position resides in the Formulation Design and Development group within Drug Product Design. The primary responsibility is to provide drug product formulation and manufacturing process design expertise in order to deliver the R & D portfolio, including hands-on support for dosage form development activities. Responsible for commercial formulation and manufacturing process design of pharmaceutical oral dosage forms (both immediate and modified release) for new drug candidates. May serve as Drug Product Lead on matrix Pharm Sci Project Teams, and leads appropriate Drug Product Sub-Team activities.







+ Leverages strong understanding of biopharmaceutics principles to design, assess and interpret experimental data, then uses the resulting information to inform selection of the optimal drug delivery strategy.



+ Designs and implements appropriate in vitro dissolution experiments to help predict the in vivo bioperformance of the drug product and translates this understanding to maximize the performance of the final drug product.



+ Utilizes appropriate predictive models and Science of Scale approaches to understand mechanical and physico-chemical characteristics of pharmaceutical compounds and formulations to drive decisions and assess performance.



+ Ensures the chemical and physical stability of dosage forms by collaborating with analytical chemists in the design of insightful and appropriate stability assessments.



+ Writes and provides guidance to writers of regulatory documents supporting drug product development, including relevant drug product sections of CTD applications and associated queries to regulatory agencies.



+ Plays a key role in cross-functional teams representing the department and works closely with colleagues in partner lines (e.g. analytical, chemistry, regulatory colleagues).



+ Provides laboratory support as needed to progress the projects.



+ Effectively mentors and develops other scientists outside of direct reports



+ Maintains an awareness of and contributes to current scientific literature; actively applies new concepts as appropriate.



+ Additional responsibilities include leading or supporting departmental initiatives such as new technology development and continuous improvement projects.







Educational Qualifications







Minimum of BS + 8 years experience, MS + 5 years experience, PhD with 0 to 4 years experience in Pharmaceutics, Chemistry, Biochemistry, Chemical Engineering, Biomedical Engineering or Biophysics preferred







Desirable







+ Experience in oral formulation development, preferably including drug delivery technologies (e.g. modified release). Demonstrated knowledge about the three pillars of drug development - biopharmaceutics, stability and manufacturability.



+ Broad technical knowledge and experience with issues related to the design and development of pharmaceutical dosage forms, related scientific problem solving, and regulatory strategy and documentation.



+ Capability and willingness to design, execute (hands-on), analyze and interpret laboratory experimentation. Strong organizational skills, interpersonal, written, and verbal communication skills.







OTHER ATTRIBUTES DESIRABLE:



Solid scientific understanding of physical pharmacy, such as solubility and dissolution kinetics, as it relates to dosage form design and bioperformance. Strong scientific leadership and direction of new technology initiatives. Established record of scientific achievement (publications, patents). Candidate should be able to work effectively as part of cross-functional teams and embrace team work.







**Sunshine Act**



Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.







**EEO & Employment Eligibility**



Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.







**Additional Offer Details:**







+ Last Date to Apply for Job: October 27, 2017



+ his job is Pfizer Exempt US/PR Grade: 008







Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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