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Senior Scientist, Gene Therapy Translational Sciences, In Vivo Group (AAV)


Cambridge, MA
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Job Details

Job Title Senior Scientist, Gene Therapy Translational Sciences, In Vivo Group (AAV)

JobID 1610401

Location: Cambridge, MA

Description The Gene Therapy Translational Science group is part of Pfizer's Rare Disease Research Unit (RDRU) focused on gene therapy specific platform technologies towards the delivery of IND-approved vectors for testing in clinical trials. This Senior Scientist will be part of an interdisciplinary team partnering closely with the RDRU Biology and Gene Therapy groups as well as colleagues in other Pfizer disciplines contributing to translational preclinical packages related to novel gene therapies. This particular lab-based role with have a strong focus on gene therapy delivery to the liver and subsequent in-depth characterization of hepatic physiology and function.


+ Execution of in vivo experiments related to delivering AAV gene therapy vectors for testing in clinical trials. Work will include optimizing AAV-based therapy formulations, routes of administration and understanding in vivo tissue distribution/cellular tropism,

+ Partner with other RDRU and WRD teams, especially pharmacokinetics and drug disposition and drug safety to develop translational preclinical packages for gene therapy clinical candidates.

+ Deliver high-value data and lead in vivo aspects of AAV-based gene therapy projects in the RDRU pipeline.

+ Execute preclinical AAV delivery studies utilizing various routes of administration.

+ Work with external collaborations and Contract Research Organizations (CROs).


+ Ph.D. in the life sciences with >2 years of post-doctoral experience.

+ Scientific training and background in liver biology, metabolic diseases, AAV in vivo delivery and evaluation of construct pharmacology.

+ Hands on experience performing and analyzing in vivo biology assays; previous work with AAV required.

+ Exceptional communication skills and demonstrated ability to work effectively as part of a team.

+ Evidence of scientific accomplishments in the form of publications and presentations.

**Additional Offer Details**

+ **Last Date to Apply for Job: December 31, 2017**

+ **Grade: 009**

+ **Location: Cambridge, MA**

+ Eligible for Employee Referral Bonus

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

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