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Senior Scientist, Immune Assays


Cambridge, MA
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Job Details


We are seeking an experienced research scientist to join the Biotherapeutics Engineering and Modality Optimization (Biomedicine Design) group. The successful candidate will be responsible for developing cell based assays primarily focused on developing immunomodulatory therapeutics (oncology and immunology/inflammation) and aiding in antibody generation, engineering and functional characterization. The candidate is expected to contribute to several therapeutic programs, design and execute immune assays utilizing a wide variety of cell lines including primary immune cells and state-of-the-art Fluorescence Assisted Cell Sorting techniques. The candidate should exhibit excellent collaborative and communication skills working on cross-functional multi-disciplinary teams.


The candidate will be responsible for:

1. Developing, optimizing and executing high throughout primary cell based binding assays, cell based immune assays (functional, phenotypic, reporter etc.) aiding in antibody generation and engineering.

2. Designing of antibody generation and screening strategy and delivering therapeutic candidates on multiple projects in collaboration with biology teams.

3. Serve as a subject matter expert in immune assays including but not limited to cytotoxicity, phagocytosis, proliferation, activation, differentiation.

4. Documenting experimental data, presenting hypotheses, experimental data, conclusions and interpretations at departmental and cross-functional team meetings.

5. Contributing to patent application examples, writing scientific publications and presenting at conferences.


BS/MS or Ph.D. in Immunology preferable Cancer Immulnology, or a related discipline with 3-5 years of research experience in academia and/or Biotech/Pharmaceutical environment, a record of significant achievements in research, scientific creativity, excellent communication and leadership skills and ability to work in a multidisciplinary, team-oriented environment.

Experience in the design, execution, and analysis of biochemical, molecular, and/or cellular assays characterizing check poit inhibitors.

Hands-on work experience in at least one of the following therapeutic areas: oncology, immunology, inflammatory or autoimmune diseases, cardiovascular and rare diseases.

Demonstrated experience in cell based assay development to aid the design & testing of therapeutics from discovery to lead-optimization

Self-motivated with extremely strong written and oral communication skills, organizational skills, demonstrated ability to work in a highly collaborative environment and ability to achieve high quality results



+ Technical proficiency with multi-color FACS and luminex

+ Culturing mammalian cells, tumor cell lines and primary immune cells

+ Proficient in setting up assays (activation, differentiation, proliferation, phagocytosis, cytotoxicity) with different immune cell subsets including T, NK, DC, MDSC and Macrophages


+ Prior experience with using immune assays in therapeutic antibody generation and engineering

+ Technical expertise in establishment and validation of cell-based assays utilizing primary cells and blood cells especially using FACS, MSD, luminex etc

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**Other Job Details:**

+ **Last Date to Apply for Job:** February 15, 2018

+ Eligible for Employee Referral Bonus: yes

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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