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Senior Scientist Materials Analysis


Sandwich, MA
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Job Details

**Senior Scientist Materials Analysis** Material Characterisation Team Location: Sandwich

**Job Purpose:**

We are seeking a scientist to work effectively within a team of motivated and self-driven colleagues to provide a combination of materials characterisation and analytical chemistry methodologies in support of product investigations within Pfizer Global Supply Network. The role will require a balance of knowledge between materials characterisation methods (ideally including microscopy, particle size analysis, powder X-ray diffraction, thermal methods and spectroscopy) and more traditional analytical methods (such as elemental analysis, chromatography and dissolution/disintegration). The successful candidate will be required to work in an innovative and autonomous manner to develop methods which are applicable for a range of pharmaceutical products (inlcluding raw materials, solid and liquid dosage forms and packaging components).

In the role, you will act as a project lead to develop experimental plans and liaise directly with a wide customer base to ensure timely delivery of results which translate complex data sets into usable knowledge for the customer. The role will require collaboration with colleagues within the Pfizer Global Supply organisations, plant and center groups, to ensure material characterisation and analytical methodologies are appropriately employed during troubleshooting investigations. Furthermore, tools will be employed to support product investigations in a pro-active manner to increase product understanding. Projects supported will range from in-depth evaluations of an active pharmaceutical (API) or other raw material, deconstruction of the important material attributes in solid or liquid dosage forms through to understanding and characterising defects in product packaging.

The role will therefore require utilisation of a wide range of material characterisation techniques. The successful candidate will be the point of accountability in the team for the utilisation and implementation of appropriate analytical procedures. This will require experience in standard analytical procedures (such as volumetric manipulations and extractions) along with fundamental understanding and practical experience in the use of analytical instruments, such as ICP, HPLC, GC and dissolution testing.

**Major Duties:**

+ Determination of chemical profiles (both organic and elemental) of API's, excipients, drug products and packaging materials to enable understanding of composition and impurities including development of appropriate sample preparation method.

+ Led for ICP-MS instrumentation and associated methodologies.

+ Measurement of dissolution, disintegration and wetting behaviour of dosage forms to enable understanding of product performance along with determination of solubility and supersaturation rates of API's.

+ Measurement of the physical attributes of API's, excipients and drug product intermediates using a range of characterisation techniques including a broad range of particle size measurements.

+ Determination of solid state attributes for API's, excipients and drug product intermediates using a range of characterisation and thermodynamic techniques.

+ Investigation of drug product construct and impact to product performance.

+ Using theoretical and practical knowledge of the manufacturing processes for both active pharmaceutical ingredients and drug product to enable materials characterisation work to underpin API, formulation and/or processing changes.

+ Identification and evaluation of novel characterisation and analytical technologies, along with development of existing technology platforms.

+ Evaluating, interpreting and reporting of results through presentations and technical reports, particularly translation of scientific output and technical content into a language understood by wide customer base.

+ Supporting implementation of safety and GMP procedures where appropriate

+ Scientific and project leadership

**Educations, Skills and Experience:**

+ Degree in a relevant subject

+ Evidence of sustained level of achievement

+ Practical experience in a relevant environment.

+ Ability to learn and apply established procedures in a reliable and consistent manner.

+ Experience in the measurement and characterisation needs of modern pharmaceutical production.

+ Experience of practical aspects of materials characterisation development

+ Experience in practical application of solid state characterisation methods (such as X-ray diffraction, thermal methods and spectroscopy)

+ Experience in application of particle characterisation techniques (such as particle sizing and surface area measurement)

+ Experience in planning, performing and reporting experimental programmes.

+ Experience in the application of spectroscopic methods in understanding pharmaceutical products

+ Proven experience in the application of analytical methods in measurement of organic materials.

+ A thorough theoretical understanding and practical ability in the development of physical property methods, including both diffraction and image analysis particle size.

+ Ability to determination dissolution and precipitation rates in pharmaceutical drug products.

+ A sound technical understanding and practical ability in the use of standard analytical procedures (such as volumetric manipulations and extractions).

+ Proven practical experience in the development of analytical methods using chromatography (IC, GC or HPLC).

+ Demonstrated practical experience in the application of elemental methods for quantification of impurities.

+ Understanding of the principles of solid state characterisation.

+ Understanding of spectroscopic methods and their application to pharmaceuticals including appropriate utilisation of spectroscopic mapping and imaging methods for pharmaceutical matrix evaluations.

+ Evidence of good laboratory and experimental skills.

+ Ability to independently design and carry out experiments.

+ Understanding of statiscal and chemometric approaches for data analysis and interpretation.

+ Sound scientific judgement in own work and in problem solving

+ Innovative and creative approach to problem solving

+ Contributions to project strategy and direction

+ Good awareness of laboratory safety

+ Sound skills in literature searching and application of findings

**Closing Statement**

This position holds a UK Grade 08.

The closing deadline for applications is Thursday 25th January 2018

We will only accept applications from colleagues via the formal route within Workday. Please do not submit paper or e-mail applications.

In line with good development planning, colleagues should discuss their suitability and/or readiness for a vacancy with their line manager prior to application. Colleagues are required to inform their manager if they are invited to attend interview. Where a line manager is not able to support an application either for suitability, readiness or business reasons, and a colleague continues to make an application, it is possible that an offer may not be made or may be withdrawn.

Applications not received by the closing date will only be accepted in exceptional circumstances and will require the support of your senior management team.

All applicants must have the relevant authorisation to live and work in the UK.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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