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Senior Scientist, Metabolism


Cambridge, MA
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Job Details

Within the Internal Medicine Research Unit (IMRU), one of the Metabolism group's key focuses is identifying novel therapies to improve metabolic homeostasis in patients suffering from cachexia across various chronic illnesses like cancer and heart failure. Our goal is to build an exciting team focused on deep mechanistic understanding of energy metabolism in cachexia, including of the homeostatic neurocircuitries underlying appetite regulation and weight loss and weight maintenance, as well as other metabolic pathways relevant to cachexia. The aim is to recruit a scientifically and technically strong neural circuitry expert with knowledge in whole body metabolism to join the team with a common goal of developing drugs to combat metabolic diseases.

**Responsibilities and qualifications:**

The successful candidate is expected to possess strong technical skills in rodent stereotaxic surgery and injections, mouse genetics and immunohistochemistry as well as in the areas of brain slice electrophysiology, optogenetics. Mechanistic understanding of metabolic and reward circuitry are essential. Proficiency in using state-of-the-art electrophysiology and optogenetics techniques is desirable.

Successful candidates will be expected to:

+ Apply scientific and technical expertise to drug discovery programs to impact the future of new drug candidate development

+ Conceptualize and design experiments

+ Organize and conduct in vivo/ ex vivo/ in vitro studies independently (including preparation, data collection, interpretation, and presentation)

+ Maintain awareness of scientific and technical developments in field

+ Author manuscripts for quality publications in top-tier journals.

+ Attend and present at team meetings and collaborate across groups in the research unit.

**Minimum Qualifications:**

+ PhD with a minimum of 2 years of post-doc experience, with a successful track record of scientific achievements through scientific publications and presentations. Expertise and hands on experience in metabolic and reward circuitry of appetite regulation are essential.

+ Possess strong written/verbal communication skills and ability to effectively collaborate with scientists working in other disciplines including neuroscience, chemistry, drug metabolism, drug safety and clinical medicine.

+ Drug discovery experience is a plus but not required.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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