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Senior Scientist, Oncology Target


Pearl River, NY
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Job Details

We are seeking a highly motivated and innovative PhD-level scientist to join the Target Discovery Group in Pfizer's Oncology Research & Development organization. The successful applicant will employ multiple genomic and functional genomic platforms to identify and validate novel small molecule or antibody drug targets. The primary therapeutic focus of this position will be leading programs to define novel immune-oncology targets but the successful candidate will be expected to be additionally capable of contributing to research programs to identify synthetic lethal oncology targets arising from tumor genetic vulnerabilities.


The successful candidate will work independently as part of a research team that is focused on identifying and validating novel cancer drug targets. The candidate is expected to utilize expertise in the fields of molecular and cellular biology, cancer biology, immunology and functional genomics to design, execute and interpret experiments and intellectually drive programs to develop novel oncology targets for therapeutic intervention.

The successful candidate will need to work seamlessly with multiple research groups within the Oncology department including colleagues in Oncology Target Discovery groups and interface with scientists across partner lines, including Tumor Cell Biology, In Vivo Pharmacology, and Computational Biology.

**Specific technical duties include:**

+ Utilize molecular and cellular biology skills including molecular biology, FACS sorting and analysis, lentiviral shRNA and CRISPR knockdown technologies followed by global MiSeq analysis to execute high-throughput genomic screens.

+ Apply both genetic and pharmacologic approaches to modulate target candidates in vitro to assess the functional impact on both immune and cancer cell biology. These include RNAi, CRISPR, small molecules, antibodies and other pharmacologic approaches to perturb gene targets in vitro and develop molecular, cellular and phenotypic assays for functional analysis.

+ Establish and execute molecular and cell-based assays across a wide variety of technical platforms (qPCR, Western blotting, FACS, immunofluorescence, ELISA, HCS etc.) to assess target modulation and its impact on immune function and tumor-susceptibility, cell viability and cell cycle disruption, transcription and downstream signal transduction.

+ Utilize expertise in cancer biology to design, execute, and analyze experiments to advance mechanism of action target biology and develop innovative approaches for targeting cancer. Coordinate with In Vivo Pharmacology group to validate target candidates in animal models.

+ Utilize electronic data capture/analysis tools such as Excel, GraphPad, Biobook, Spotfire and PowerPoint for experimental documentation and data analysis/presentations

+ Present experimental results at both internal group meetings in the Oncology Research & Development organization and through external meetings and publications.

**Educational Requirements:**

PhD in Cancer Biology, Immunology, Cell Biology (or a comparable biological science) plus minimum 1 year post-doctoral training or equivalent experience in cancer biology, immunology, cell signaling or a related discipline. Well-qualified candidates will have a track record of scientific accomplishments as evidenced by a strong publication record.

+ Deep knowledge of literature in areas of both immune and tumor cell biology in addition to strong motivation and creativity required to drive drug discovery target programs.

+ Hands-on experience in in multiple molecular and cellar biology techniques including genetic manipulation, generation of engineered cell lines, high-throughput assays, flow cytometry, phenotypic assays are required.

+ Background encompassing immuno-oncology and/or experience in target identification/validation is a plus.

+ Strong interpersonal skills and excellent communication abilities are required for this role.

**Technical Skill Requirements:**

+ Technical knowledge of cancer biology including oncogenic signaling pathways and/or expertise in immune cell biology is required.

+ Expertise in molecular biology, mammalian cell culture techniques and cell-based functional assays is required.

+ Expertise in gene knockdown technologies utilizing RNAi and CRISPR platforms, gene expression analysis (qPCR, Western blotting, FACS analysis) and cell-based phenotypic assays is critical.

+ Strong track record in screening approaches for target identification, utilization of inhibitors or genetic manipulations for target validation and/or expertise in immune-oncology is highly valued.

+ Excellent verbal/written communication and interpersonal skills with an emphasis on working in a team environment to accomplish impactful results.

+ Ability to work in a fast paced dynamic environment. Self-motivation and demonstrated capability to independently drive research programs.

**Physical/Mental Requirements:**

+ Job requires laboratory work which includes extended periods of sitting and standing

**Other Job Details:**

+ Eligible for Relocation Package

+ Eligible for Employee Referral Bonus

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.T

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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