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Senior Scientist, Oncology Therapeutics Discovery


Pearl River, NY
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Job Details

Job Title Senior Scientist, Oncology Therapeutics Discovery

JobID 1045808-1852

Location: Pearl River, NY

Description *About Pfizer*

A career at Pfizer offers opportunity, ownership and impact.All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

*Role Description*

We seek a creative, enthusiastic, and highly motivated cancer biologist to join the Oncology Therapeutics Discovery Group located in Pearl River, New York. The preferred candidate should have a deep understanding of tumor cell signaling with a focus on ER stress and a strong motivation to harness this knowledge for drug discovery toward impactful therapies for cancer patients.


The successful candidate will work independently as part of a research team that is focused on the identification and validation of novel therapeutic targets.Specific responsibilities include:*Utilize expertise in cell signaling, ER stress, metabolism and cancer immunology to design, execute, and analyze/interpret experiments to uncover novel areas of cancer biology that can be exploited therapeutically to maximize patient response.*Apply genetic and pharmacologic approaches to modulate tumor intrinsic and TME targets and assess the functional impact on cancer initiation and progression. Execute molecular and cell-based assays across various technology platforms to assess target modulation and measure downstream signaling pathways - high content screening, FACS, immunofluorescence, immunoblotting, ELISA, other multiparametric readout platforms. *Demonstrate a high level of initiative in leading a project work-stream, troubleshooting experiments, performing data analysis, maintaining lab notebooks and ensuring cross-line engagement. Strong commitment to collaboration with other members of the Oncology R&D Unit and supporting partner lines as part of a project team. Highly organized in terms of goal setting and deliverables.*Highly effective communication and presentation skills, both written and oral, with ability to clearly articulate scientific hypotheses, results and conclusions to project teams and governance bodies. *Conduct research that leads to publication in peer-reviewed journals and presentation of data at internal and external meetingsOrganizational Relationships:Reports to a group leader within the Oncology Therapeutic Discovery Group. Collaborate with colleagues in Functional Genomics, Proteomics & Metabolomics, and Transcriptomics groups. Interface with scientists across partner lines, including Tumor Cell Biology, In Vivo Pharmacology, Oncology Translational Research, Computational Biology, Chemistry and Drug Safety R&D.


Requirements for this position include a PhD degree plus post-doctoral training or equivalent experience in cancer biology, cell signaling, tumor metabolism or a related discipline. Well-qualified candidates will have a track record of scientific accomplishments as evidenced by a very strong publication record. Deep understanding of tumor cell signaling / ER stress / metabolism /immuno-oncology is needed plus strong motivation to harness this knowledge for drug discovery. Hands on experience in cell and molecular biology techniques including genetic/chemical manipulation, generation of engineered cell lines, high content/throughput assays, flow cytometry, phenotypic assays are strongly preferred. Experience in target identification / validation is a plus. Strong motivation, interpersonal skills and excellent communication abilities are needed for this role.Technical/Additional Skills:- Strong understanding of tumor cell biology and cell /stress signaling pathways.- Experience in target identification/ validation and screening approaches using small-molecule inhibitors , chemical biology tools and/or genetic manipulation (shRNA, CRISPR, etc) is required- Preference for candidates with additional expertise in immuno-oncology and immune regulation- Strong experience working as part of a cross-functional team- Excellent verbal/written communication and interpersonal skills- Extended periods of sitting and standing

*EEO & Employment Eligibility*

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

*Senior Scientist, Oncology Therapeutics Discovery*
*Pearl River, New York*

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