Sign In
 [New User? Sign Up]
Mobile Version

Senior Scientist, Process Development

Pfizer


Location:
Groton, CT
Date:
12/07/2017
2017-12-072018-01-07
Pfizer
Apply on the Company Site
  •  
  • Save Ad
  • Email Friend
  • Print
  • Research Salary

Job Details

**ROLE SUMMARY**



We are seeking a chemical engineer to join the Chemical Research and Development (CRD) team in Groton. The successful candidate will join a dynamic team responsible for developing robust scalable processes for use at pilot plant and commercial scale. They will apply chemical engineering principles, modeling, and lab-scale data-rich experimentation to increase process understanding and to optimize the processes for safety, efficiency, and robustness.







CRD, as part of Worldwide R&D in Pharmaceutical Sciences, is responsible for the development of process technology for the production of API. CRD scientists engage in all facets of development from small scale synthesis in support of medicinal chemistry programs, to the development of the commercial synthetic route. CRD scientists partner with manufacturing specialists for API synthesis in kilo-lab and pilot plant facilities, as well as provide support for technology transfer to Pfizer manufacturing sites and third party facilities.







The successful candidate as a part of the project team will partner closely with chemists and analysts to identify optimal technology (batch, semi-batch, continuous) and process operating conditions. They will then support technology transfer and scale up of the developed process in our pilot plant and commercial manufacturing facilities. Given the dynamic team environment, strong interpersonal and communication skills are essential.







**ROLE RESPONSIBILITIES**







+ Apply chemical engineering principles, modeling tools, and experimental skills using data-rich laboratory instrumentation to improve process understanding and assess proposed process modifications.



+ Apply an understanding of plant equipment capabilities and operations to assess scalability and robustness for API processes.



+ Select, develop, and apply new and existing process technologies to facilitate process design to achieve project goals.



+ Supports technology transfer of drug substance processes to internal Pfizer API manufacturing facilities and external suppliers. May spend time at the PGS launch site supporting process validation and Pre-Approval Inspection (PAI) activities.



+ Contributes to the preparation of the Chemistry and Manufacturing Controls (CMC) section of the New Drug Application (NDA). Participates in data verification, PAI preparedness, and post submission query response. Collaborate and prepare internal research reports and technical presentation.



+ Champion the development of novel laboratory instrumentation and software modeling tools to improve process understanding. Leads the development and implementation of new and existing workflows and methodologies.



+ Remains current with the process engineering and chemistry literature. May collaborate and author external publications and present research at external conferences.







**QUALIFICATIONS**



Education:







+ MS in Chemical Engineering with 2-5 years of experience or PhD in Chemical Engineering with 0-4 years of relevant experience required.







Required Skills:







+ Excellent knowledge of chemical engineering principles including: reaction kinetics, reactor design, chemical thermodynamics, heat and mass transport, engineering statistics, modeling and simulation.







Preferred Skills:







+ Working knowledge of reaction modeling, property prediction, and simulation computational tools including: DynoChem, Visimix, Aspen, Fluent, and Cosmotherm



+ Working knowledge of UPLC, MS, and NMR



+ Experience with continuous manufacturing processes



+ Experience in automating laboratory and/or manufacturing processes



+ Working knowledge of application of in-situ analysis tools to process understanding including: FTIR, FBRM, UV/Vis



+ A demonstrated foundational understanding of organic chemistry







**NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS**



Some travel associated with technology transfer to CRD pilot plant and PGS new product launch site may be required.







**EEO & Employment Eligibility**



Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.







**Sunshine Act**



Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.







**Other Job Details:**



Eligible for Relocation Package



Eligible for Employee Referral Bonus







Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
Apply on the Company Site
Powered ByLogo

Featured Jobs[ View All ]

Featured Employers [ View All ]