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Senior Scientist, Upstream Process Development, Gene Therapy

Pfizer


Location:
Durham, NC
Date:
11/17/2017
2017-11-172017-12-18
Pfizer
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Job Details

**ROLE SUMMARY**



The Senior Scientist in upstream process development will help drive the development of Pfizer's Gene Therapy platform. The incumbent should be highly motivated, results-oriented, and a self-starter who demonstrates personal accountability for outcomes and thrives on increasing levels of responsibility. As a member of the Bioprocess R&D development department, the Senior Scientist will design and execute mammalian cell bioreactor experiments in bench-top bioreactors with the goal of developing robust, scalable, and highly productive processes that produce viral vectors with the appropriate product quality to treat human disease.







**ROLE RESPONSIBILITIES**



The successful Senior Scientist will have advanced experience in upstream process development. This position will join a larger team of scientists across multiple sites focused on developing and optimizing cell culture processes for recombinant viral vectors for early- and late-phase clinical trials. The job function requires sound scientific judgment and innovation using advanced practices and procedures to achieve solutions. The Senior Scientist will be expected to design and conduct experiments, evaluate the study results, develop and test new hypotheses to improve the fundamental understanding of upstream cell culture processes. This position will support process validation, quality by design, regulatory approaches, and innovative research as well as prepare internally reviewed technical reports, and make oral presentations to scientists and management.



Specific Roles



Design and execute mammalian cell culture experiments with the goal of developing robust and scalable processes for viral vectors with appropriate product quality attributes for clinical applications



Demonstrates leadership and capability to mentor junior colleagues, and fosters a team environment



Ability to troubleshoot scientific and technical challenges, and contribute to their resolution



Analyze and communicate experimental results both orally and in written reports to colleagues and management



Ensures effective, high-quality, timely and appropriate documentation in laboratory notebooks and internal Technical Reports



Contribute to equipment procurement, laboratory set up and organization



Contributes to a safe, efficient and effective lab environment with personal accountability







**QUALIFICATIONS**



PhD degree with 0-3 years or Master's degree with 6+ years of postgraduate experience in biotech/ biopharma industry in the development and characterization of mammalian cell culture processes.







Advanced experience in upstream bioprocessing in a laboratory setting, including knowledge of state-of-the-art equipment and industrial cell culture



Demonstrated ability to drive for results and generate innovative solutions with minimum supervision. Applicants should be self-motivated, organized, and capable of working independently and in a collaborative environment. The successful candidate will possess strong oral and written communication skills.



Mastery of lab scale bioreactor systems and work with computerized process control equipment



Experience in transferring bioprocesses to pilot plants or manufacturing (cGMP) organizations and knowledge of data acquisition and controls systems in these environments is a plus.



Strong attention to detail. Ability to execute detailed experimental plans, record procedures, analyze data, and present results



Takes the initiative to solve scientific problems and drive their resolution



Experience with statistical experimental design and analysis of biological processes.



Able to work in a fast paced team environment with changing priorities







**EEO & Employment Eligibility**



Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.







**Sunshine Act**



Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.







**Additional Offer Details:**







+ **Last Date to Apply for Job:** January 1, 2018



+ **This job is Pfizer Exempt (US/PR) Grade:** 008



+ Eligible for Employee Referral Bonus: yes



+ Eligible for relocation: yes







Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
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