Sign In
 [New User? Sign Up]
Mobile Version

Sr. Associate Scientist, AAV Viral Prep

Pfizer


Location:
Virtual
Date:
08/17/2017
2017-08-172017-09-15
Job Code:
1054407
Pfizer
Apply on the Company Site
  •  
  • Save Ad
  • Email Friend
  • Print

Job Details

Job Title Sr. Associate Scientist, AAV Viral Prep

JobID 1054407

Location: Virtual, USA

Description A career at Pfizer offers opportunity, ownership and impact.



All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.



Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



Colleagues who are issued an Incident Final Warning (IFW) on or after January 1, 2016, are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.



Education: A BS, BA or MS with relevant laboratory experience or equivalent experience in Biological Sciences, Biochemical engineering or a related fields.

• Minimum of 2 years of experience in a similar capacity

• Undergrad degree required



• Extensive experience in AAV vector manufacturing is essential.

• Extensive experience in the culture of mammalian cell lines and microbial cells either in adherent or suspension system is essential

• Prior work with WAVE and stir tank bioreactors and downstream process equipment is essential

• Prior experience in small scale cell culture is essential

• Experience with a variety of basic molecular biology techniques, such as cloning, western blots/Elisa, assay development etc would be advantageous

• Understanding CL2 safety requirements, practice of good sterile techniques, and prior work experience with viruses and mammalian cells including HEK293, is essential

• Ability to develop and follow detailed SOPs

• Demonstrated history of successful troubleshooting and experimental design

• Excellent communication and interpersonal skills.

• Ability to assemble and communicate scientific data



The role will be part of a small, but expanding team, that will have the responsibility for manufacturing research grade AAV-based gene therapy vectors to support early product development and AAV candidate selection. The role will involve working with equipment necessary for small-scale production of various AAV vectors and DNA plasmids. The individual must be able to conduct work with a quality mindset.



• Serve as a senior associate scientist for research grade DNA plasmid and AAV vector manufacturing who reports directly to the Senior Director overseeing multiple projects

• Manufacturing of AAV or other viral vectors for the purpose of aiding in the AAV candidate selection process for gene therapy programs.

• Manufacturing AAV vectors to support R&;D experimentation using shaker flasks, WAVE bioreactors, stir tank bioreactors, transfection, centrifugation, and chromatography techniques.

• Manufacturing of plasmid DNA to support AAV manufacturing and cloning projects

• Work with Senior Scientist and relevant teams to carry out project plans and meet timelines to support the early development of gene therapy programs

• Ensure high quality core support for projects.

• Ensure manufacturing supplies and reagents are available for use when needed

• Must ensure detailed lab notebooks are part of daily activities

• Support internal and external collaboration, through direct interactions, data analysis, and work plan alignment.

• Maintain laboratory in accordance with GLP-like practices.

• Establish SOP's specific to the manufacturing job roles and activities to ensure consistency.

• Understand and follow various Pfizer guidelines.



This position is to be managed through Bamboo Therapeutics as part of the Rare Disease Research Unit. The position will have interactions with multiple functional lines within the company including the Pharmacological Sciences. In addition, the unit is designed to operate in a highly networked manner.



The Rare Diseases Research Unit (RDRU) of Pfizer is committed to the development of new therapies to address unmet medical needs of those individuals with rare and neglected diseases and to make a real impact on patient lives.



This is a really exciting time for Pfizer RDRU, which has recently established Bamboo Therapeutics in Chapel Hill, NC. Our laboratory is dedicated to the discovery and development of Gene Therapy based products and our commitment to rare disease research and to genetic medicine development is expected to be an area of tremendous growth in the coming years. Bamboo is fitted with state-of-the art laboratories and equipment, providing the perfect environment for cutting-edge science and exciting projects



This individual will be working closely with fellow R&;D scientists to manufacture research grade plasmid DNA and AAV viral vectors to support AAV candidate selection for future gene therapy applications.



This position offers a challenging and exciting opportunity for implementing and learning different microbial and mammalian cell culture techniques and to solve complex biological problems. It also brings a unique chance to collaborate with talented and dedicated colleagues across the world while developing and expanding your career. The ideal candidate is a highly talented and self-motivated individual with a strong scientific background.A career at Pfizer offers opportunity, ownership and impact.



All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.



Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.


Apply on the Company Site
Powered By

Featured Jobs[ View All ]

Featured Employers [ View All ]