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Sr. Principal Scientist, CAR T Product Molecular and Cell


South San Francisco, CA
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Job Details

Job Title Sr. Principal Scientist, CAR T Product Molecular and Cell

JobID 1046438-1852

Location: South San Francisco, CA

Description *About Pfizer*

A career at Pfizer offers opportunity, ownership and impact.All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

*Role Description*

We are seeking a highly motivated, results-oriented, self-starter who demonstrates personal accountability for outcomes and thrives on increasing levels of responsibility, to join a new and dynamic team responsible for developing clinical manufacturing processes and characterization of allogeneic Chimeric Antigen Receptor T cell (CART) therapies.The successful candidate will lead efforts to develop heightened CART product understanding through application of molecular and T cell biology approaches to identify and measure attributes and/ or biomarkers critical for safety, functional activity and consistency of this novel engineered cell therapy modality, and work in close collaboration with key stakeholders, including the CART Research and Analytical R&D groups.


-Provide senior, strategic and technical, molecular immunology/ T cell biology leadership for cell and molecular characterization of allogeneic CART products, and starting donor PBMCs, to inform product understanding, process/ product relationships and batch-to-batch consistency-Lead/ contribute to the establishment of methods to characterize and understand the impact of cell engineering steps on the genome, biology and function of CART cell products - particularly with regard to product safety (on-/ off-target effects and translocations) and efficacy-Lead/ contribute to the establishment of methods to characterize and understand the impact of donor-to-donor variability on engineered CART product genotype and phenotype with regard to safety (potential for alloreactivity/ GvHD) and efficacy-Lead/ contribute to the establishment of programs to identify relevant biomarkers for desired CART potency and safety characteristics and to demonstrate product consistency (donor-to-donor/ process changes)-Lead/ contribute to relevant and impactful innovation programs (internally and external collaborations) to enhance CART characterization technologies and work-processes, aligned with emerging business drivers and Regulatory expectations-Contribute to Project Technical Teams to ensure effective integration at all levels. Communicate and collaborate effectively to ensure seamless interfaces and interactions within the group and across all stakeholder groups-Demonstrate strong leadership, personal accountability and interpersonal skills, and capability for mentoring junior colleagues (direct reports and others), and establish safe, high-quality lab practices-Ensure high-quality, timely documentation in electronic laboratory notebooks and Technical Reports, and contribute to Regulatory Filings and responses to Regulatory questions as appropriate-Present data/ strategy to scientists and management in internal and external venues (technical meetings, Project Team meetings, conferences) and publish in peer-reviewed journals, as appropriate-Maintain familiarity with the relevant current literature and its application to CART characterization and understanding


Education & Experience: PhD degree in Immunology/ Molecular Biology with 10 years of post-graduate experience in relevant roles in academia/ industry, in the development of methods/ tools for investigation and characterization of T cell genotype, phenotype and function - preferably for cell-based therapies.Technical Skills Requirements:-T cell biology, molecular immunology, 'omics analysis, NGS (bioinformatics a plus)-Leading and managing a team-Ability to design and deliver novel solutions to challenging problems - a track record of innovation and publicationPHYSICAL/MENTAL REQUIREMENTS:Ability to perform complex data analysisAbility to analyze and interpret work published in the field and use it to place own work in contextNON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS:Some travel to other Pfizer sites and national/ international collaborators may be required

*EEO & Employment Eligibility*

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

*Sr. Principal Scientist, CAR T Product Molecular and Cell*
*South San Francisco, California*

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