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Sr. Scientist


Pearl River, NY
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Job Details

Job Title Sr. Scientist

JobID 1046522-1852

Location: Pearl River, NY

Description *About Pfizer*

A career at Pfizer offers opportunity, ownership and impact.All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

*Role Description*

We seek a creative and highly self-motivated biologist with experience in protein engineering. This role is to develop and enhance existing oncology biotherapeutic target discovery through the development of tumor targeted and conditionally activated biotherapeutics. These will include the design of immunomodulatory biotherapeutics by combining antibody development with rational synthetic biological design.


A successful candidate will work independently and as part of a research team that is focused on the identification and validation of novel biotherapeutic targets, should have a deep understanding of protein and antibody engineering with a focus on biotherapeutic engineering, and an interest in the development of tumor targeted and conditionally regulated biotherapeutics for solid tumors.Specific responsibilities include:The candidate will utilize expertise in rational protein and cancer immunomodulatory designs to produce, characterize, execute, and analyze/interpret experiments to uncover cancer biology that can be exploited through biotherapeutics approaches aimed at maximizing patient response.This will include executing molecular and cell based assays across various technology platforms to assess biotherapeutic performance using ELISA, FACS, immunofluorescence, and other multi-parametric platforms.Potential candidate should demonstrate a high level of initiative in leading project work-stream to a completion. This includes troubleshooting experiments, performing data analysis, ensuring collaborative team engagement, being highly organized and maintaining accurate lab notebooks, and setting and achieving milestones, goals and timelines. Strong commitment to collaboration with other members of the Oncology R&D Unit and supporting partner lines as part of a project team will be essential to success. Highly effective communication and presentation skills, both written and oral, with ability to clearly articulate scientific hypotheses, results and conclusions to project teams. Conduct research that leads to publication in peer-reviewed journals and presentation of data at internal and external meetingsOrganizational Relationships:Reports to a Director within the Oncology Therapeutic Discovery Group. Collaborate with colleagues in Proteomics & Metabolomics, Functional Genomics, and Transcriptomics groups. Interface with scientists in the Oncology Research Targeted Therapeutic Development group and across partner lines, including In Vivo Pharmacology Computational Biology, and Biomedical Design organizations.


Requirements for this position include a Ph.D. degree plus 1-2 years' post-doctoral training or equivalent experience in protein engeineering, biotherapeutic development, synthetic biology, cancer biology, cancer immunology or related disciplines. We have a preference for candidates with additional expertise in T and Natural Killer cell modulation and the design of immunomodulatory ligands.Technical Skills:Strong motivation, interpersonal skills and excellent communication abilities are needed for this role. Experience in solid tumor biotherapeutic target identification / validation is a plus.Specific technical duties include:- Proficient with protein modeling, ligand-receptor docking and other computational approaches to assist in rational protein design (through Discovery Studio or equivalent)- Proficient in antibody production, purification and biophysical characterization- Experience in antibody-antigen interaction studies through high density peptide array and other molecular characterization strategies- Experience in developing cellular assay and executing molecular and cell-based assays across various technology platforms to assess biotherapeutic performance that include quantitative tumor targeting and immune-modulation metrics.- Excellent verbal/written communication and interpersonal skills- Excel in working as part of an innovative and collaborative teamPHYSICAL/MENTAL REQUIREMENTS May require extended time of both standing and computational analysis.

*Other Information - Internal*

Colleagues who are issued an Incident Final Warning (IFW) on or after January 1, 2016, are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.

*EEO & Employment Eligibility*

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

*Sr. Scientist*
*Pearl River, New York*

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