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Structural Biology Sr. Scientist, Protein Sciences


San Diego, CA
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Job Details

Job Title Structural Biology Sr. Scientist, Protein Sciences

JobID 1607383

Location: San Diego, CA

Description Pfizer Worldwide Research and Development La Jolla, has an open position for a talented and creative research scientist in the Structural Biology and Protein Sciences (SBPS) Group within the Department of Oncology Medicinal Chemistry. Candidates who have demonstrated an ability to carry out innovative and high quality research to answer challenging and complex questions in structural biology are of particular interest.

The successful candidate will have significantly demonstrated expertise in exploiting protein biophysical methods to enable challenging structural biology. The candidate will work independently and as part of teams to provide biophysical insights toward ensuring that protein deliveries are fit-for-purpose (primarily X-ray crystallography, cryoEM and biochemical assay), establishing SBDD platforms and impacting projects at a strategic level. In addition to hands-on experimental work, the position requires the ability to train colleagues, ensure functionality and calibration of existing instrumentation, and lead the identification and utilization of emerging technologies to strengthen and further build on current capabilities within SBPS.

Basic Qualifications:

+ Minimum requirements for candidates are a PhD and postdoctoral experience in Biophysics, Structural Biology or a closely related field.

The ideal candidate will have a solid biophysics background and possess significant expertise in multiple of the following areas:

1) biophysical characterization (AUC, DSC, fluorescence spectroscopy, SAXS, SEC-MALS and DLS) of proteins and macromolecular complexes.

2) analysis of protein-ligand (protein:small molecule, protein:protein and protein:nucleic acid) interactions (e.g. ITC, SPR, MST) - ideally with expertise for weak affinity ligands (fragments) and covalent inhibitors.

3) ability to integrate new, impactful and cutting-edge protein biophysical methods to strengthen and further build on current capabilities within SBPS.

A working knowledge of protein characterization requirements for Cryo-EM analysis would be helpful. Familiarity with protein hydrogen-deuterium exchange mass spectrometry (structural dynamics) and NMR will be beneficial.

Candidates will also possess the following attributes:

+ Excellent oral and written communication skills

+ Excellent interpersonal skills which facilitate knowledge sharing and scientific discussions

+ Ability to quickly and effectively operate, communicate and influence decision making within cross-functional and multi-disciplinary drug discovery teams

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Additional Information:

+ Grade: 8

+ Eligible for Relocation Package

+ Eligible for Employee Referral Bonus

A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

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